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Testosterone concentration and insulin sensitivity in young men with type 1 and type 2 diabetes

机译:年轻人患有1型和2型糖尿病的睾丸激素浓度和胰岛素敏感性

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Objective: Reduced testosterone, a recognized comorbidity of reduced insulin sensitivity (IS) and type 2 diabetes (T2D), has also been reported in adult males with type 1 diabetes (T1D). However, there are limited data on how early reduced testosterone occurs, and whether it is related to the reduced IS in T1D. Leptin, a modulator of the HPG-axis, may also influence testosterone in T1D. We hypothesized that IS and leptin would be associated with total testosterone (TT), and free androgen index (FAI) in adolescent males with T1D.
机译:目的:睾丸激素降低是公认的胰岛素敏感性降低(IS)和2型糖尿病(T2D)合并症,在成年男性1型糖尿病(T1D)中也有报道。但是,关于早期睾丸激素减少如何发生以及它是否与T1D中IS减少有关的数据有限。瘦素是HPG轴的调节剂,也可能影响T1D中的睾丸激素。我们假设IS和瘦素与T1D青春期男性的总睾丸激素(TT)和游离雄激素指数(FAI)相关。

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