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首页> 外文期刊>Pediatric diabetes. >Improved metabolic outcome in a Danish diabetic paediatric population aged 0-18 yr: results from a nationwide continuous Registration.
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Improved metabolic outcome in a Danish diabetic paediatric population aged 0-18 yr: results from a nationwide continuous Registration.

机译：丹麦0-18岁糖尿病小儿人群的代谢改善：来自全国范围的持续注册。

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摘要

The objective of the present study was to describe the changes in glycaemic control based on data from the nationwide Danish Registry of Childhood Diabetes with valid haemoglobin A1c (HbA1c) readings centrally analysed between 1996 and 2006. The glycaemic control was assessed using generalized linear mixed models. Centre, age, diabetes duration, ethnicity, sex, self-monitoring of blood glucose, insulin regimens and hypoglycaemia was tested as explanatory variables. There were 9291 HbA1c recordings from 2705 children with T1D during the 10-yr period. The unadjusted mean HbA1c value in 1997 was 9.05% (95% CI +/- 0.82) and in 2006 was 8.20% (95% CI +/- 0.06). Mean HbA1c was significantly reduced over the years with a linear decrease of 0.08% per year (95% CI +/-0.011) (p < 0.0001). The decrease was unaffected by adjusting for number of injections, insulin/kg and use of insulin analogous. During the period, an increased frequency of self-monitored blood glucose was observed that was associated with a reduction in HbA1c (p < 0.0001). The percentage of children with severe hypoglycaemia decreased from 12.2 to 7.8% in those with HbA1c between 6 and 8%. Metabolic control in diabetic children has improved on a nationwide basis from the establishment of the national registry in 1996. The reduction in HbA1c was related to an increased number of self-monitoring of blood glucose values and a decrease in the number of hypoglycaemic events in those with the best metabolic control, whereas there were no association with the use of new analogous or insulin regimens.
机译：本研究的目的是根据全国儿童糖尿病登记处的数据描述血糖控制的变化，并有效分析1996年至2006年之间的有效血红蛋白A1c（HbA1c）读数。使用广义线性混合模型评估了血糖控制。测试中心，年龄，糖尿病病程，种族，性别，血糖自我监测，胰岛素治疗方案和低血糖作为解释变量。在10年期间，共有2705名T1D儿童患上了9291份HbA1c记录。 1997年未经调整的平均HbA1c值为9.05％（95％CI +/- 0.82），2006年为8.20％（95％CI +/- 0.06）。多年来，平均HbA1c显着下降，每年线性下降0.08％（95％CI +/- 0.011）（p <0.0001）。通过调整注射次数，胰岛素/ kg和类似胰岛素的使用量，减少量不会受到影响。在此期间，观察到自我监测血糖的频率升高，这与HbA1c的降低有关（p <0.0001）。 HbA1c在6％至8％之间的儿童，严重低血糖的比例从12.2％降至7.8％。自1996年建立国家注册机构以来，糖尿病儿童的代谢控制已在全国范围内得到改善。HbA1c的降低与这些儿童血糖值自我监测的数量增加以及降血糖事件的数量减少有关具有最佳的代谢控制，而与使用新的类似疗法或胰岛素疗法没有关联。

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