Expression of insulin-like growth factor 1 and insulin-like growth factor 1 receptor is associated with the favorable clinicopathologic parameters in small intestinal carcinomas

ShinH.C.; BaeY.K.; GuM.J.; JungE.S.; OhY.-H.

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Expression of insulin-like growth factor 1 and insulin-like growth factor 1 receptor is associated with the favorable clinicopathologic parameters in small intestinal carcinomas

机译：胰岛素样生长因子1和胰岛素样生长因子1受体的表达与小肠癌的良好临床病理参数相关

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Objective: The insulin-like growth factor (IGF) system has been known to play a critical role in tumor development and progression in many human cancers. However, the role of the IGF system in small intestinal carcinoma (SIC) has not been studied yet. Methods: We evaluated the expression of IGF1 and IGF1 receptor (IFG1R) in a total of 194 cases of SIC. Results: IGF1 expression was associated with well/moderate differentiation, better survival, lower pT, lower stage and no lymph node metastasis. IGF1R was more diffusely and strongly expressed in tumors with lower pT and lower stage. Conclusions: IGF1 and IGF1R expression is associated with favorable clinicopathologic parameters and may involve early carcinogenesis of SICs. Target therapy for the IGF1R signaling pathway may not have a major therapeutic role in treating SIC.

机译：目的：胰岛素样生长因子（IGF）系统在许多人类癌症的肿瘤发生和发展中起着至关重要的作用。但是，尚未研究IGF系统在小肠癌（SIC）中的作用。方法：我们评估了总共194例SIC患者中IGF1和IGF1受体（IFG1R）的表达。结果：IGF1表达与良好/中度分化，更好的生存率，更低的pT，更低的阶段以及无淋巴结转移相关。 IGF1R在较低pT和较低分期的肿瘤中更弥散和强烈表达。结论：IGF1和IGF1R的表达与良好的临床病理参数有关，可能与SICs的早期癌变有关。 IGF1R信号通路的靶标治疗可能在治疗SIC中没有主要的治疗作用。

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《Pathobiology: journal of immunopathology, molecular and cellular biology》 |2013年第5期|共6页
作者
ShinH.C.; BaeY.K.; GuM.J.; JungE.S.; OhY.-H.;
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正文语种 eng
中图分类病理学;
关键词
Carcinoma; Immunohistochemistry; Insulin-like growth factor 1; Insulin-like growth factor 1 receptor; Insulin-like growth factor system; Small intestine;

机译：癌;免疫组化;胰岛素样生长因子1;胰岛素样生长因子1受体;胰岛素样生长因子系统;小肠;

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1. Expression of insulin-like growth factor 1 and insulin-like growth factor 1 receptor is associated with the favorable clinicopathologic parameters in small intestinal carcinomas [J] . ShinH.C., BaeY.K., GuM.J., Pathobiology: journal of immunopathology, molecular and cellular biology . 2013,第5期

机译：胰岛素样生长因子1和胰岛素样生长因子1受体的表达与小肠癌的良好临床病理参数相关
2. Impact of insulin-like growth factor 2, insulin-like growth factor receptor 2, insulin receptor substrate 2 genes polymorphisms on susceptibility and clinicopathological features of hepatocellular carcinoma [J] . RashadN.M., El-ShalA.S., AbdElbaryE.H., Cytokine . 2014,第1期

机译：胰岛素样生长因子2，胰岛素样生长因子受体2，胰岛素受体底物2基因多态性对肝细胞癌易感性和临床病理特征的影响
3. Insulin-like growth factor-1 receptor inhibition induces a resistance mechanism via the epidermal growth factor receptor/HER3/AKT signaling pathway: rational basis for cotargeting insulin-like growth factor-1 receptor and epidermal growth factor receptor in hepatocellular carcinoma. [J] . Desbois Mouthon C, Baron A, Blivet Van Eggelpoel MJ Clinical cancer research: an official journal of the American Association for Cancer Research . 2009,第17期

机译：胰岛素样生长因子-1受体抑制通过表皮生长因子受体/ HER3 / AKT信号传导途径诱导耐药机制：在肝细胞癌中共同靶向胰岛素样生长因子-1受体和表皮生长因子受体的合理依据。
4. NOVEL APPROACHES WITH HEPATITIS B CORE CARRIER IN THE GROWTH CONTROL OF HepG2 BY BLOCKADE OF INSULIN-LIKE GROWTH FACTOR-Ⅰ RECEPTOR (IGF-IR) [C] . Jing Kong, Zhengyu Diao, Xiaozhao Deng, 第四届国际后基因组生命科学技术学术论坛 . 2006

机译：胰岛素样生长因子-Ⅰ受体（IGF-IR）阻滞HepG2生长控制的新型肝癌载体的新方法
5. Suppressor of cytokine signaling-2 (SOCS2) and epidermal growth factor (EGF) modulate insulin-like growth factor-I receptor (IGF-IR) signaling in intestinal cancer. [D] . Newton, Victoria A. 2010

机译：细胞因子信号传导抑制因子2（SOCS2）和表皮生长因子（EGF）的抑制因子调节肠癌中胰岛素样生长因子-I受体（IGF-IR）的信号传导。
6. Expression of receptors for epidermal growth factor and insulin-like growth factor I by ZR-75-1 human breast cancer cell variants is inversely related: the effect of steroid hormones on insulin-like growth factor I receptor expression. [O] . H. W. van den Berg, D. Claffie, M. Boylan, 1996

机译：ZR-75-1人乳腺癌细胞变异体表达表皮生长因子和胰岛素样生长因子I的受体呈负相关：类固醇激素对胰岛素样生长因子I受体表达的影响。
7. Expression of Insulin-Like Growth Factor 1 and Insulin-Like Growth Factor 1 Receptor is Associated with the Favorable Clinicopathologic Parameters in Small Intestinal Carcinomas [O] . Hyung Chan Shin, Young Kyung Bae, Mi Jin Gu, 2013

机译：胰岛素样生长因子1和胰岛素样生长因子1受体的表达与小肠癌中有利的临床病理参数有关
8. Insulin-Like Growth Factor Binding Protein-1 Interacts with Integrins to Inhibit Insulin-Like Growth Factor-Induced Breast Cancer Growth and Migration [R] . Gross, J. M. 2003

机译：胰岛素样生长因子结合蛋白-1与整合素相互作用，抑制胰岛素样生长因子诱导的乳腺癌生长和迁移

Expression of insulin-like growth factor 1 and insulin-like growth factor 1 receptor is associated with the favorable clinicopathologic parameters in small intestinal carcinomas

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