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首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >Cancer stem cells in breast: current opinion and future challenges.
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Cancer stem cells in breast: current opinion and future challenges.

机译：乳房癌干细胞：当前观点和未来挑战。

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摘要

There is increasing evidence for the cancer stem cell hypothesis, which holds that cancers are driven by a cellular subcomponent that has stem cell properties, that is, self-renewal, tumorigenicity and multilineage differentiation capacity. The cancer stem cell hypothesis modifies our conceptual approach of oncogenesis and shall have implications in breast cancer prevention, detection and treatment, especially in metastatic breast cancer for which no curative treatment exists. Given the specific stem cell features, novel therapeutic pathways can be targeted. Following this approach, new molecules are currently in development. Focusing on the cross-talk between stem cells and their microenvironment is also a promising way to explore how to better target cancer stem cells and be curative.
机译：越来越多的证据表明，癌症干细胞假说认为癌症是由具有干细胞特性（即自我更新，致瘤性和多系分化能力）的细胞亚成分驱动的。癌症干细胞假说改变了我们关于肿瘤发生的概念方法，将对乳腺癌的预防，检测和治疗产生影响，特别是对于没有治愈性治疗方法的转移性乳腺癌。给定特定的干细胞特征，可以靶向新的治疗途径。按照这种方法，目前正在开发新分子。关注干细胞与其微环境之间的相互作用也是探索如何更好地靶向癌症干细胞并治愈的一种有前途的方法。

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