• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >Atherothrombosis and plaque heterology: different location or a unique disease?
【24h】

Atherothrombosis and plaque heterology: different location or a unique disease?

机译：动脉粥样硬化和斑块异质性：不同的位置还是独特的疾病？

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Formation of unstable plaques frequently results in atherothrombosis, the major cause for ischaemic stroke, myocardial infarction and peripheral arterial disease. Patients who have symptomatic thrombosis in one vascular bed are at increased risk of disease in other beds. However, the development of the disease in carotid, coronary and peripheral arteries may have different pathophysiology suggesting that more complex treatment protocols may have to be designed to reduce plaque development at different locations. In this review we describe the known risk factors, compare the developmental features of coronary and carotid plaque development and determine their association with end-point ischaemic events. Differences are also seen in the genetic contribution to plaque development as well as in the deregulation of gene and protein expression and cellular signal transduction activity of active cells in regions susceptible to thrombosis. Differences between carotid and coronary artery plaque development might help to explain the differences in anatomopathological appearance and risk of rupture.
机译：不稳定斑块的形成经常导致动脉血栓形成，这是缺血性中风，心肌梗塞和周围动脉疾病的主要原因。在一张血管床中有症状性血栓形成的患者在另一张床中患病的风险增加。但是，颈动脉，冠状动脉和外周动脉疾病的发展可能具有不同的病理生理学，提示可能必须设计更复杂的治疗方案以减少不同部位的斑块发展。在这篇综述中，我们描述了已知的危险因素，比较了冠状动脉和颈动脉斑块的发育特征，并确定它们与终点缺血事件的关系。在对斑块形成的遗传贡献以及基因和蛋白质表达的失调以及在易形成血栓的区域中活性细胞的细胞信号转导活性方面也发现了差异。颈动脉和冠状动脉斑块发育之间的差异可能有助于解释解剖病理学外观和破裂风险的差异。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号