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首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >Protective effects of vitamin E and selenium on the renal morphology in rats fed high-cholesterol diets.
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Protective effects of vitamin E and selenium on the renal morphology in rats fed high-cholesterol diets.

机译：维生素E和硒对高胆固醇饮食喂养的大鼠肾脏形态的保护作用。

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摘要

The histopathological effects of cholesterol and the protective effects of vitamin E and selenium (Se) on renal histology were examined in Sprague-Dawley rats. Light-microscopic evaluation of the renal cortex revealed: glomerular fibrosis, cellular and mesangial proliferation, capillary obliteration and cholesterol crystals in the tubular lumina of the cholesterol-fed group. These results suggest that oxidated LDL (O-LDL) is a cytotoxic factor which stimulates mesangial cell and matrix proliferation. Ultrastructurally, small and large lipid vacuolization in intracapillary lumina, adhesion of epithelial foot processes, mesangial foam cells and polymorphonuclear leukocytes were seen in the cholesterol-fed group. In the groups fed cholesterol + vitamin E, cholesterol + Se and cholesterol + vitamin E + Se, morphological improvements were observed. It appeared that an excess in O-LDL, reactive oxygen species and growth factors might play an important role in the pathogenesis of glomerulosclerosis. In addition, it was concluded that antioxidant therapy may prevent LDL oxidation and generation of free radicals. Copyright 2001 S. Karger AG, Basel
机译：在Sprague-Dawley大鼠中检查了胆固醇的组织病理学作用以及维生素E和硒（Se）对肾脏组织学的保护作用。肾皮质的光学显微镜评估显示：胆固醇喂养组的肾小管腔内有肾小球纤维化，细胞和肾小球膜增生，毛细血管闭塞和胆固醇晶体。这些结果表明，氧化的LDL（O-LDL）是一种刺激肾小球膜细胞和基质增殖的细胞毒性因子。在胆固醇喂养组中，在毛细血管内腔中存在超微结构，大小脂质脂质空化，上皮足突粘附，肾小球系膜泡沫细胞和多形核白细胞。在饲喂胆固醇+维生素E，胆固醇+ Se和胆固醇+维生素E + Se的组中，观察到形态学改善。似乎过量的O-LDL，活性氧和生长因子可能在肾小球硬化的发病机理中起重要作用。此外，得出的结论是抗氧化剂治疗可以防止LDL氧化和自由基的产生。版权所有2001 S. Karger AG，巴塞尔

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