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首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >Hypoxia-induced tumour cell migration in an in vivo chicken model.
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Hypoxia-induced tumour cell migration in an in vivo chicken model.

机译：在体内鸡模型中低氧诱导的肿瘤细胞迁移。

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摘要

To investigate the relationship between hypoxia, neovascularisation and tumour cell spread, experiments on the area vasculosa of the early chick embryo under different oxygen concentrations were performed in vivo. Human glioblastoma cells (U-138MG) were inoculated onto the area vasculosa and the fertilised eggs were incubated under conditions of normoxia or hypoxia. For evaluation, we performed in vivo video-microscopy of the area vasculosa and determination of microvessel density (MVD), as well as a histological examination of the fixed specimen. Under hypoxia, MVD was significantly increased compared to normoxic conditions. Only under hypoxic conditions was tumour cell spread found outside the main tumour mass and within the vessels, at times followed by the subsequent development of secondary tumour cell bulks on the area vasculosa. These data lead to the conclusion that hypoxia can stimulate tumour cell migration in this in vivo model. Copyright 2001 S. Karger AG, Basel
机译：为了研究缺氧，新血管形成和肿瘤细胞扩散之间的关系，在体内进行了在不同氧气浓度下早期雏鸡胚胎的血管区域的实验。将人成胶质细胞瘤细胞（U-138MG）接种到血管区域，将受精卵在常氧或低氧条件下孵育。为了进行评估，我们在体内进行了血管区域的视频显微镜检查并确定了微血管密度（MVD），并对固定标本进行了组织学检查。在缺氧条件下，MVD与常氧条件相比明显增加。仅在低氧条件下，肿瘤细胞才在主要肿瘤块内和血管内扩散，有时随后在血管区域继发继发性肿瘤细胞散布。这些数据得出结论，在该体内模型中，缺氧可以刺激肿瘤细胞迁移。版权所有2001 S. Karger AG，巴塞尔

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