首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >Bronchus-associated lymphoid tissue (BALT) is not present in the normal adult lung but in different diseases.
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Bronchus-associated lymphoid tissue (BALT) is not present in the normal adult lung but in different diseases.

机译:支气管相关淋巴样组织(BALT)在正常成人肺中不存在,但在不同疾病中均存在。

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摘要

Bronchus-associated lymphoid tissue (BALT) was first described in the lungs of rabbits and differs greatly between species. It is part of the integrated mucosal immune system. This review clarifies its morphological definition and focuses on the situation in humans. The frequency of BALT at different ages, after chronic stimulation and in different diseases is described. In healthy humans, BALT can only be found in the lungs of children and adolescents. The role of BALT in lung transplantation and in the development of low-grade malignant lymphomas in the airways is also discussed. Furthermore, questions concerning the inducibility of BALT as an entry site for vaccines, and the regulation of its activity for future therapeutic interventions in pulmonary immune reactions are addressed. Copyright 2000 S. Karger AG, Basel.
机译:支气管相关淋巴样组织(BALT)首先在兔的肺中被描述,并且在种间差异很大。它是整合粘膜免疫系统的一部分。这篇评论澄清了其形态学定义,并着眼于人类的处境。描述了不同年龄,慢性刺激后和不同疾病中BALT的发生频率。在健康的人类中,BALT仅存在于儿童和青少年的肺部。还讨论了BALT在肺移植和气道低度恶性淋巴瘤发生中的作用。此外,还讨论了有关BALT作为疫苗进入位点的可诱导性及其对肺免疫反应未来治疗性干预活动的调节的问题。版权所有2000 S. Karger AG,巴塞尔。

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