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Macrophage biology and pathobiology in the evolution of immune responses: a functional analysis.

机译:免疫应答进化中的巨噬细胞生物学和病理生物学:功能分析。

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A number of general principles of macrophage biology and pathobiology are formulated to define the contribution of macrophages to the kinetics and sequencing of innate and adaptive immune responses more precisely. The application of these principles to modelling immune responses and to macrophage-based treatments of immune disorders is discussed. The concept of innate peripheral tolerance is developed. It is suggested that macrophage activation could be a primary determinant of nearly every aspect of immune responsiveness, both normal and abnormal, as might be predicted from the innate immune response to 'danger' being evolutionarily more primitive than the adaptive. Copyright 2002 S. Karger AG, Basel
机译:制定了许多巨噬细胞生物学和病理生物学的一般原理,以更精确地定义巨噬细胞对先天和适应性免疫反应的动力学和测序的贡献。讨论了这些原理在模拟免疫反应和基于巨噬细胞的免疫疾病治疗中的应用。发展了先天性外周耐受性的概念。有人提出,巨噬细胞的活化可能是正常和异常免疫应答几乎每个方面的主要决定因素,这可以从先天免疫应答中预测,“危险”在进化上比适应性更原始。版权所有2002 S. Karger AG,巴塞尔

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