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首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >Leukocyte infiltration of the periarterial space of the lung after allergen provocation in a rat asthma model.
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Leukocyte infiltration of the periarterial space of the lung after allergen provocation in a rat asthma model.

机译：在大鼠哮喘模型中，变应原激发后，肺动脉周围空间的白细胞浸润。

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摘要

The periarterial space has recently been described and its physiological and pathophysiological role during inflammatory and allergic reactions has been reviewed. The present studies used a light-/electron-microscopic approach to characterize the periarterial space in an asthma model in Brown Norway rats. After repeated sensitization with ovalbumin and heat-killed Bordetella pertussis bacilli, airway challenge was carried out after 1 further week. Four or 24 h after challenge, rats were fixed by perfusion or instillation and processed for microscopy. Several periarterial capillaries and connective tissue characterized the tissue between small pulmonary arteries, bronchioles and alveolar septa. Additionally, a partly pronounced interstitial edema was seen independent of the kind of fixation. Not only small arteries but also arterioles and venules were partly surrounded by edematous fluid already visible by light microscopy. Within the connective tissue and within the periarterial fluid, numerous leukocytes, predominantly eosinophils, were found. However, leukocytes were detected only rarely in the vascular lumen. Only sporadically were eosinophils seen in the wall of small arteries or venules. Eosinophils transmigrating the endothelium of capillaries or arterioles were not visible 4 or 24 h after challenge. Thus, granulocytes transmigrate in the periarterial space very rapidly or even earlier than 4 h after challenge. The location of transmigration in the periarterial space needs further investigation.
机译：最近已经描述了动脉周间隙，并且已经综述了其在炎症和变态反应期间的生理和病理生理作用。本研究使用光/电子显微镜方法来表征布朗挪威大鼠哮喘模型中的动脉周围间隙。用卵清蛋白和热灭活的百日咳博德特氏菌反复致敏后，再过1周进行气道攻击。攻击后4或24小时，通过灌注或滴注将大鼠固定并进行显微镜检查。几个动脉周围毛细血管和结缔组织的特征是小肺动脉，细支气管和肺泡间隔之间的组织。另外，观察到部分明显的间质性水肿，与固定方式无关。不仅小动脉而且小动脉和小静脉被光学显微镜已经可见的水肿液部分包围。在结缔组织内和动脉周液中，发现了许多白细胞，主要是嗜酸性粒细胞。然而，在血管腔中仅很少检测到白细胞。仅在偶发性小动脉或小静脉壁上可见嗜酸性粒细胞。攻击后4或24小时看不到嗜酸性粒细胞迁移到毛细血管或小动脉的内皮。因此，粒细胞在攻击后4小时内非常迅速地甚至甚至早于在动脉周围空间中迁移。转运在动脉周围空间的位置需要进一步调查。

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