SYNTHESIS AND ANTIVIRAL ACTIVITY OF SEVERAL QUINOLINE DERIVATIVES

M. N. Zemtsova; A. V. Zimichev; P. L. Trakhtenberg; Yu. N. Klimochkin; M. V. Leonova; S. M. Balakhnin; N. I. Bormotov; O. A. Serova; E. F. Belanov

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SYNTHESIS AND ANTIVIRAL ACTIVITY OF SEVERAL QUINOLINE DERIVATIVES

机译：几种喹啉衍生物的合成及其抗病毒活性

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The antiviral activity of 2-substituted and 2,6-disubstituted quinoline-4-carboxylic acids and their derivatives has been studied against orthopoxviruses on Vero and MK-2 cell cultures. High activity has been found for 2-( 1,1 '-biphenyl-4-yl)quinoline-4-carboxylic acid.Compounds with antibacterial and antifungal properties have been found among 2-mono- and 2,6-disubstituted quinoline-4-carboxylic acids and their derivatives [1,2]. The goal of the present work was to find new antiviral drugs in a series of compounds (I-XIV). 2-Mono- and 2,6-disubstituted quinoline-4-carboxylic acids I, IV, VI, and VIII were prepared by Pfitzinger cyclization of the corresponding methylketones with isatin in basic medium [3, 4].

机译：已经研究了2-取代的和2,6-二取代的喹啉-4-羧酸及其衍生物的抗病毒活性，它们在Vero和MK-2细胞培养物中对抗正痘病毒。已发现2-（1,1'-联苯-4-基）喹啉-4-羧酸具有高活性，在2-单-和2,6-二取代的喹啉4中发现具有抗菌和抗真菌特性的化合物-羧酸及其衍生物[1,2]。当前工作的目标是在一系列化合物中找到新的抗病毒药物（I-XIV）。通过在碱性介质中用靛红对相应的甲基酮进行Pfitzinger环化反应，制得2-单-和2,6-二取代的喹啉-4-羧酸I，IV，VI和VIII [3，4]。

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《Pharmaceutical Chemistry Journal》 |2011年第5期|共3页
作者
M. N. Zemtsova; A. V. Zimichev; P. L. Trakhtenberg; Yu. N. Klimochkin; M. V. Leonova; S. M. Balakhnin; N. I. Bormotov; O. A. Serova; E. F. Belanov;
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正文语种 eng
中图分类药学;
关键词
quinolinecarboxylic acids; acid derivatives; biological activity.;

机译：喹啉羧酸;酸衍生物;生物活性;

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SYNTHESIS AND ANTIVIRAL ACTIVITY OF SEVERAL QUINOLINE DERIVATIVES

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