• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effects of heroin/cocaine combinations in rats trained to discriminate heroin or cocaine from saline.
【24h】

Effects of heroin/cocaine combinations in rats trained to discriminate heroin or cocaine from saline.

机译：海洛因/可卡因组合对从盐水中区分海洛因或可卡因的大鼠的影响。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The effects of heroin and cocaine administered alone or in combination were examined in rats trained to discriminate either heroin (0.56 mg/kg i.p.; n = 6) or cocaine (5.6 mg/kg i.p.; n = 6) from saline. Heroin (0.032-1.8 mg/kg) substituted completely for the heroin training stimulus in all six heroin-trained rats, but failed to substitute for cocaine in any of the cocaine-trained rats. Cocaine (0.1-32 mg/kg) substituted completely for the cocaine training stimulus in all six cocaine-trained rats, and substituted for heroin in two of six heroin-trained rats. The opioid antagonist naltrexone (0.01-1.0 mg/kg) antagonized the discriminative stimulus effects of heroin, but naltrexone at doses up to 10 mg/kg had no effect on the discriminative stimulus effects of cocaine. The dopamine receptor antagonist flupenthixol (0.032-0.56 mg/kg) attenuated the discriminative stimulus effects of heroin and completely blocked the discriminative stimulus effects of cocaine. When heroin-cocaine combinations were administered to the heroin-trained rats, cocaine (1-5.6 mg/kg) did not significantly alter the mean heroin dose-effect curve. Similarly, in the cocaine-trained rats, heroin (0.1-0.56 mg/kg) did not significantly alter the mean cocaine dose-effect curve. These results suggest that combinations of heroin and cocaine usually produce discriminative stimulus effects similar to either heroin or cocaine alone.
机译：在接受过训练以区分盐水中的海洛因（0.56 mg / kg腹膜内; n = 6）或可卡因（5.6 mg / kg腹膜内; n = 6）的大鼠中，检查了单独或组合使用海洛因和可卡因的效果。海洛因（0.032-1.8 mg / kg）在所有六只海洛因训练的大鼠中完全替代了海洛因训练刺激，但在任何可卡因训练的大鼠中均未能替代可卡因。可卡因（0.1-32 mg / kg）在所有六只可卡因训练的大鼠中完全替代了可卡因训练刺激，在六只海洛因训练的大鼠中的两个中完全替代了海洛因。阿片样物质拮抗剂纳曲酮（0.01-1.0 mg / kg）拮抗海洛因的歧视性刺激作用，但纳曲酮的最高剂量10 mg / kg对可卡因的歧视性刺激作用无作用。多巴胺受体拮抗剂氟喷他醇（0.032-0.56 mg / kg）减弱了海洛因的歧视性刺激作用，并完全阻断了可卡因的歧视性刺激作用。当海洛因-可卡因组合被给予海洛因训练的大鼠时，可卡因（1-5.6 mg / kg）不会显着改变平均海洛因剂量-效应曲线。同样，在可卡因训练的大鼠中，海洛因（0.1-0.56 mg / kg）也没有显着改变可卡因的平均剂量效应曲线。这些结果表明，海洛因和可卡因的组合通常产生区别性刺激作用，类似于单独使用海洛因或可卡因。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号