Implication of endogenous opioid system in the learned helplessness model of depression.

Tejedor Real P; Mico JA; Maldonado R; Roques BP; Gibert Rahola J

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Implication of endogenous opioid system in the learned helplessness model of depression.

机译：内源性阿片样物质系统在学习的抑郁无助模型中的意义。

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The involvement of opioid system on the learned helplessness model of depression was investigated. Animals preexposed to inescapable shocks were treated with either Met-enkephalin, Leu-enkephalin, morphine, imipramine, naloxone, RB 38A (a mixed inhibitor of enkephalin degrading enzymes), or RB 38B (a selective inhibitor of neutral endopeptidase EC 3.4.24.11). Stimulation of opioid system by either opioid agonists or enkephalin catabolism inhibitors reversed the escape deficit induced by shock pretreatment. In contrast, administration of naloxone potentiated the effect of inescapable shocks. Imipramine reduced the number of escape failures in this test, and this effect was antagonized by naloxone. These results point to the involvement of the endogenous opioid system in this model of depression.

机译：阿片类药物系统参与学习的抑郁无助模型的研究。预先暴露于不可避免的电击中的动物用Met-脑啡肽，Leu-脑啡肽，吗啡，丙咪嗪，纳洛酮，RB 38A（脑啡肽降解酶的混合抑制剂）或RB 38B（中性内肽酶EC 3.4.24.11的选择性抑制剂）处理。。阿片激动剂或脑啡肽分解代谢抑制剂对阿片系统的刺激可逆转休克预处理引起的逃逸缺陷。相反，纳洛酮的给药增强了不可避免的电击的效果。丙咪嗪减少了该测试中逃逸失败的次数，纳洛酮拮抗了这种作用。这些结果表明内源性阿片样物质系统参与了这种抑郁模型。

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《Pharmacology, Biochemistry and Behavior》 |1995年第1期|共8页
作者
Tejedor Real P; Mico JA; Maldonado R; Roques BP; Gibert Rahola J;
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正文语种 eng
中图分类药理学;
关键词
Depression; Endorphins; Helplessness; Learned; Antidepressive Agents; Tricyclic; 抑郁症; 内啡肽类; 无助状态; 学习;

机译：Depression;Endorphins;Helplessness;Learned;Antidepressive Agents;Tricyclic;抑郁症;内啡肽类;无助状态;学习;

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1. Implication of endogenous opioid system in the learned helplessness model of depression. [J] . Tejedor Real P, Mico JA, Maldonado R, Pharmacology, Biochemistry and Behavior . 1995,第1期

机译：内源性阿片样物质系统在学习的抑郁无助模型中的意义。
2. Remodeling of hippocampal spine synapses in the rat learned helplessness model of depression. [J] . Hajszan T, Dow A, Warner Schmidt JL, Biological psychiatry . 2009,第5期

机译：大鼠海马棘突触的重塑学会了抑郁症的无助模型。
3. Reduced expression of glutamate transporters vGluT1, EAAT2 and EAAT4 in learned helpless rats, an animal model of depression. [J] . Zink M, Vollmayr B, Gebicke Haerter PJ, Neuropharmacology . 2010,第2期

机译：在学习型无助大鼠（一种抑郁症的动物模型）中，谷氨酸转运蛋白vGluT1，EAAT2和EAAT4的表达降低。
4. To model learned helplessness: is depression a maladaptive response of a rational system? [C] . David C. Moffat Annual Convention of the Society for the Study of Artificial Intelligence and Simulation of Behaviour . 2017

机译：模型学习无助：抑郁症是一个合理系统的不良反应吗？
5. Neuropsychopharmacology and molecular pharmacology of the cannabinoid system in the learned helpless model of depression. [D] . Niwatananun, Wirat. 2000

机译：所学习的抑郁无助模型中大麻素系统的神经心理药理学和分子药理学。
6. Hypertensive Effect of Downregulation of the Opioid System in Mouse Model of Different Activity of the Endogenous Opioid System [O] . Dominik S. Skiba, Piotr Szczepaniak, Mateusz Siedliński, 2021

机译：内源性阿片体系不同活性小鼠模型中阿片类药物下调的高血压作用
7. Dissociation of learned helplessness and fear conditioning in mice: a mouse model of depression. [O] . Dominic Landgraf, Jaimie Long, Andre Der-Avakian, 2015

机译：老鼠学习无助和恐惧条件的分离：抑郁症的小鼠模型。
8. Endogenous Opioid Systems: Physiological Role in the Self-Limitation of Seizures [R] . Tortella, F. C., Long, J. B., Holaday, J. W. 1985

机译：内源性阿片类药物系统：癫痫发作自限性的生理作用

Implication of endogenous opioid system in the learned helplessness model of depression.

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