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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Enhanced locomotor stimulation by NMDA receptor antagonists in alcohol-sensitive ANT rats.
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Enhanced locomotor stimulation by NMDA receptor antagonists in alcohol-sensitive ANT rats.

机译：NMDA受体拮抗剂在酒精敏感性ANT大鼠中增强了运动刺激。

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The ability of the antagonists for the N-methyl-D-aspartate (NMDA) type of glutamate receptor to modulate locomotor activity were compared in alcohol-sensitive (or alcohol-nontolerant, ANT) and alcohol-insensitive (or alcohol-tolerant, AT) rat lines. Both rat lines showed altered locomotor activity after acute injections of a competitive antagonist (LY235959), a glycine-site antagonist (L-701,324), or noncompetitive antagonists [MK-801, phencyclidine (PCP), and ketamine] of the NMDA receptor. MK-801 at 0.5 mg/kg caused a strong increase in horizontal activity in both rat lines, the effect being significantly greater in the ANT rats. There was a subpopulation among AT rats that was almost completely unresponsive to MK-801. This insensitivity to MK-801 correlated with the lack of c-fos induction in the retrosplenial and cingulate cortices. Fos immunoreactive cells in these brain regions after MK-801 treatment were more numerous in ANT than AT rats, although c-fos induction in the inferior olivary nucleus was similar in all animals after MK-801. The ANT rats showed greater locomotor stimulation also after ketamine and LY235959, while stimulation induced by PCP and depression induced by L-701,324 did not differ between the rat lines. The data suggest that altered NMDA receptor-mediated processes may correlate with differences in innate alcohol sensitivity in the ANT/AT rat model.
机译：在酒精敏感性（或非酒精耐受性，ANT）和酒精敏感性（或酒精耐受性，AT）中比较了拮抗剂的N-甲基-D-天冬氨酸（NMDA）型谷氨酸受体调节运动活性的能力。 ）鼠线。急性注射NMDA受体的竞争性拮抗剂（LY235959），甘氨酸位点拮抗剂（L-701,324）或非竞争性拮抗剂[MK-801，苯环利定（PCP）和氯胺酮]后，两只大鼠品系均显示出运动能力改变。 0.5 mg / kg的MK-801在两条大鼠品系中均引起水平活动的强烈增加，而在ANT大鼠中其作用明显更大。在AT大鼠中有一个亚群，几乎完全不响应MK-801。对MK-801的这种不敏感性与脾后和扣带状皮质中缺乏c-fos诱导有关。在MK-801处理后，这些大脑区域的Fos免疫反应性细胞在ANT中比在AT大鼠中多，尽管在MK-801处理后的所有动物中，下橄榄核的c-fos诱导均相似。在氯胺酮和LY235959之后，ANT大鼠也表现出更大的运动刺激，而PCP诱导的刺激和L-701,324诱导的抑郁在各系之间没有差异。数据表明，改变的NMDA受体介导的过程可能与ANT / AT大鼠模型中先天酒精敏感性的差异有关。

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