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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Lack of NMDA receptor involvement in caffeine-induced locomotor stimulation and tolerance in rats.
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Lack of NMDA receptor involvement in caffeine-induced locomotor stimulation and tolerance in rats.

机译：NMDA受体缺乏参与咖啡因诱导的运动刺激和大鼠耐受性。

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The involvement of NMDA-type glutamate receptors in caffeine's locomotor stimulant effects and the development of tolerance to these effects was examined in rats. Caffeine and the noncompetitive NMDA receptor antagonists, MK-801 and phencyclidine (PCP), were examined alone and in combination. Caffeine produced a biphasic dose-effect curve. Both MK-801 and PCP increased locomotor activity at the highest doses tested. MK-801 and PCP shifted the caffeine curve upward, but only with the highest doses that increased locomotor activity when given alone. For the tolerance experiment, osmotic pumps containing either MK-801 or nothing at all and were implanted in rats that were given either caffeinated or drug-free tap water to drink. All rats drinking caffeine showed tolerance to its locomotor stimulant effects, whereas rats drinking drug-free tap water did not. Chronic infusion of MK-801 (0.1 and 0.3 mg/kg/day) failed to block the development of tolerance to caffeine. The 0.3 mg/kg/day infusion of MK-801 appeared to slightly delay the development of tolerance to caffeine, but this effect was probably due to the locomotor stimulant effects of this infused dose of MK-801 alone. These data provide no evidence that NMDA-type glutamate receptors play a crucial role in mediating caffeine's locomotor stimulant effects or tolerance to these effects.
机译：在大鼠中检查了NMDA型谷氨酸受体在咖啡因的运动刺激作用中的参与以及对这些作用的耐受性的发展。咖啡因和非竞争性NMDA受体拮抗剂MK-801和苯环利定（PCP）单独或组合检查。咖啡因产生了双相剂量效应曲线。在测试的最高剂量下，MK-801和PCP均可提高运动活性。 MK-801和PCP使咖啡因曲线向上移动，但仅在最高剂量下单独使用时，可增加运动能力。对于耐受性实验，将不包含MK-801或根本不包含MK-801的渗透泵植入大鼠中，饮用含咖啡因或无毒品的自来水。所有喝咖啡因的大鼠都表现出对它的运动刺激作用的耐受性，而喝无毒品自来水的大鼠则没有。长期输注MK-801（0.1和0.3 mg / kg /天）未能阻止对咖啡因的耐受性。每天以0.3 mg / kg / kg的剂量注入MK-801似乎会稍微延迟对咖啡因的耐受性，但是这种作用可能是由于单独注入MK-801的运动刺激作用所致。这些数据没有证据表明NMDA型谷氨酸受体在介导咖啡因的运动刺激作用或对这些作用的耐受性中起关键作用。

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