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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Lesion of the median raphe nucleus: a combined behavioral and microdialysis study in rats.
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Lesion of the median raphe nucleus: a combined behavioral and microdialysis study in rats.

机译：中缝沟核的病变：大鼠行为和微透析的联合研究。

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摘要

The purpose of the present study was to investigate the behavioral consequences and the neurochemical correlates of a 5,7-dihydroxytryptamine (5,7-DHT) lesion of the median raphe nucleus (MRN) in rats. Anxiety-related behavior was assessed in the elevated plus maze test on days 5, 14, and 21 after lesioning. In general, behavior of MRN-lesioned rats was unchanged when compared with sham-lesioned or untreated controls. Neurochemically, microinjection of 5,7-DHT into the MRN resulted in 87.5% depletion of hippocampal 5-HT content. Using the in vivo microdialysis technique, the exposure of 5,7-DHT-lesioned rats to the elevated plus-maze failed to increase extracellular 5-HT release (94%) in the hippocampus, as shown in sham-lesioned (150%) or untreated controls (194%). Moreover, application of fenfluramine (10 mg/kg, i.p.) evoked a 10-fold increase in hippocampal extracellular 5-HT levels in sham-lesioned animals, whereas in 5,7-DHT lesioned rats 5-HT was only slightly increased. The results demonstrate, that a marked reduction of 5-HT release from the MRN is not necessarily accompanied by anxiolytic-like behavior.
机译：本研究的目的是调查大鼠中位中缝核（MRN）的5,7-二羟基色胺（5,7-DHT）病变的行为后果和神经化学相关性。在损伤后第5、14和21天，在高架迷宫测试中评估与焦虑相关的行为。通常，与假手术或未治疗的对照组相比，MRN病变的大鼠的行为没有改变。从神经化学上讲，向MRN中微量注射5,7-DHT导致海马5-HT含量减少了87.5％。使用体内微透析技术，将5,7-DHT损伤的大鼠暴露于升高的正迷宫中，未能增加海马中细胞外5-HT的释放（94％），如假手术（150％）所示或未经处理的对照（194％）。此外，使用芬氟拉明（10 mg / kg，腹腔注射）引起假手术动物海马细胞外5-HT水平增加了10倍，而5,7-DHT病患大鼠中5-HT仅略有增加。结果表明，从MRN释放5-HT的显着减少不一定伴随着抗焦虑样行为。

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