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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Intra-accumbens infusion of D(3) receptor agonists reduces spontaneous and dopamine-induced locomotion.
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Intra-accumbens infusion of D(3) receptor agonists reduces spontaneous and dopamine-induced locomotion.

机译：D（3）受体激动剂的伏隔内输注减少了自发和多巴胺诱导的运动。

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摘要

The present study investigated whether PD 128907 and 7-OH-DPAT, described as preferential dopamine (DA) D(3) receptor agonists, produce hypolocomotion by acting at postsynaptic dopaminergic receptors within the nucleus accumbens. Bilateral infusion of PD 128907 (1.5 and 3 microg/0.5 microl) induced a dose-dependent hypolocomotion, whereas its enantiomer, PD 128908, was inactive. Local infusion of 7-OH-DPAT and the preferential DA autoreceptor agonist, B-HT 920, at the same dose range also decreased spontaneous locomotion. In addition, both drugs induced yawning with B-HT 920 producing the greatest effect. In the second experiment, the ability of these agonists to reduce the locomotor activity induced by intra-accumbens injection of DA (10 microg/0.5 microl) was studied. Pretreatment with either PD 128907 or 7-OH-DPAT (3 microg) reduced DA-induced hyperactivity. Local infusion of B-HT 920 (3 microg) failed to antagonise the locomotor effects of DA. Altogether these findings suggest that PD 128907 and 7-OH-DPAT induce hypolocomotion by acting in part at postsynaptic DA receptors. The possible role of D(2) and/or D(3) receptors in the mediation of these effects is discussed.
机译：本研究调查了PD 128907和7-OH-DPAT（被描述为优先多巴胺（DA）D（3）受体激动剂）是否通过作用于伏隔核内的突触后多巴胺能受体而产生运动减退。双向输注PD 128907（1.5和3微克/0.5微升）会引起剂量依赖性的运动不足，而其对映异构体PD 128908则没有活性。在相同剂量范围内局部输注7-OH-DPAT和优先DA自身受体激动剂B-HT 920也会降低自发运动。此外，两种药物都可以用B-HT 920产生打哈欠的效果最大。在第二个实验中，研究了这些激动剂降低由伏隔内注射DA（10 microg / 0.5 microl）诱导的运动活性的能力。用PD 128907或7-OH-DPAT（3微克）进行预处理可减少DA诱导的过度活跃。 B-HT 920（3微克）的局部输注未能拮抗DA的运动作用。总而言之，这些发现表明PD 128907和7-OH-DPAT通过部分作用于突触后DA受体而诱导运动不足。讨论了D（2）和/或D（3）受体在这些作用介导中的可能作用。

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