首页> 外国专利> METHOD FOR INDUCING ANALGESIA COMPRISING ADMINISTRATION ALTERNATIVELY OF AN OPIOID RECEPTOR AGONIST AND AN OPIOID RECEPTOR LIKE RECEPTOR 1 AGONIST FOR AND AN IMPLANTABLE INFUSION PUMP

METHOD FOR INDUCING ANALGESIA COMPRISING ADMINISTRATION ALTERNATIVELY OF AN OPIOID RECEPTOR AGONIST AND AN OPIOID RECEPTOR LIKE RECEPTOR 1 AGONIST FOR AND AN IMPLANTABLE INFUSION PUMP

机译：用于诱导镇痛的方法，该镇痛剂交替包含阿片受体激动剂和阿片受体类似受体1激动剂，并且用于可植入的输注泵

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摘要

A method of producing analgesia in a mammal is provided by rotational (alternating) intrathecal administration to the mammal of a pharmaceutically effective dose of at least one opioid receptor agonist, such as a mu -, delta - or kappa -opioid receptor agonist for a first period of time, followed by intrathecal administration to the mammal of a pharmaceutically effective dose of at least one opioid receptor-like receptor 1 (ORL-1) agonist for a second period of time. The intrathecal drug administration of the first and second periods of time may be repeated a plurality of times without attaining tolerance in the mammal to either drug. Implantable apparatus for rotational administration of the active agents is also disclosed.

机译：提供了一种在哺乳动物中产生镇痛的方法，该方法是通过将哺乳动物的药学上有效剂量的至少一种阿片受体激动剂（例如μ-，δ-或κ-阿片受体激动剂）旋转（交替）鞘内施用给哺乳动物来提供的。时间段内，然后在第二个时间段内向哺乳动物鞘内施用药物有效剂量的至少一种阿片样受体样受体1（ORL-1）激动剂。第一和第二时间段的鞘内给药可以重复多次，而在哺乳动物中对任一药物都没有耐受性。还公开了用于旋转施用活性剂的可植入设备。

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公开/公告号WO03004034B1

专利类型
公开/公告日2003-08-07

原文格式PDF
申请/专利权人 OMEROS CORPORATION;REGENTS OF THE UNIVERSITY OF CALIFORNIA;DEMOPULOS GREGORY A.;PALMER PAMELA PIERCE;
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申请/专利号WO2002US06721
发明设计人 DEMOPULOS GREGORY A.;PALMER PAMELA PIERCE;
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申请日2002-02-28
分类号A61K31/485;A61K31/4468;A61K31/4535;A61K31/454;A61K38/07;A61M5/142;
国家 WO
入库时间 2022-08-21 23:54:54

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