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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Reinstatement of ethanol seeking in rats: behavioral analysis.
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Reinstatement of ethanol seeking in rats: behavioral analysis.

机译：恢复大鼠寻找乙醇的行为分析。

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The reinstatement model has been repeatedly used to study relapse to heroin- or cocaine-seeking behaviour in rats. The aim of the present study was to evaluate basic behavioral parameters of cue-induced reinstatement of ethanol seeking in a within-session paradigm. Rats were trained to respond for ethanol in an oral self-administration procedure where each lever press resulted in presentation of 0.1 ml of 8% ethanol from a liquid dipper. In the reinstatement paradigm operant behaviour was first extinguished for 20 or 60 min by switching the dipper off. Then, ethanol-associated stimuli were noncontingently delivered and reinstatement of responding was assessed. Deliveries of the empty dipper, i.e., visual/auditory cues only, did not result in any reinstatement. In contrast, 15 random presentations of the dipper containing either ethanol (4-8%; v/v) or water significantly reinstated ethanol seeking. In a control self-administration experiment responding dropped to nonsignificant levels when water was substituted for ethanol. The magnitude of reinstatement did not depend on the duration of the extinction phase. These results seem to indicate that in the present paradigm reinstatement of ethanol seeking is driven by a compound stimulus including the visual/auditory cues and some nonspecific sensory properties of liquid available in the dipper.
机译：恢复模型已被反复用于研究大鼠海洛因或可卡因寻求行为的复发。本研究的目的是评估会话内范式中线索诱导乙醇还原的基本行为参数。训练大鼠以口服自我给药的方式对乙醇作出反应，其中每次按下杠杆都会从浸液中产生0.1 ml的8％乙醇。在恢复范例中，首先通过关闭北斗来熄灭操作行为20或60分钟。然后，与乙醇相关的刺激被非连续地递送，并且评估了应答的恢复。空铲斗的交付（即仅视觉/听觉提示）不会导致任何恢复。相比之下，含有乙醇（4-8％; v / v）或水的北斗星的15个随机表示大大恢复了对乙醇的寻找。在对照自我管理实验中，当用水代替乙醇时，响应下降到不明显的水平。恢复的幅度不取决于灭绝阶段的持续时间。这些结果似乎表明，在当前的范例中，乙醇的寻找是由复合刺激驱动的，包括视觉/听觉暗示以及浸入器中可用液体的一些非特异性感觉特性。

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