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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >The influence of buspirone, and its metabolite 1-PP, on the activity of paroxetine in the mouse light/dark paradigm and four plates test.
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The influence of buspirone, and its metabolite 1-PP, on the activity of paroxetine in the mouse light/dark paradigm and four plates test.

机译：丁螺环酮及其代谢物1-PP在小鼠明/暗范式和四板试验中对帕罗西汀活性的影响。

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摘要

Although numerous animal procedures have been employed in the study of antidepressants (ADs) in anxiety, the results following acute administration remain highly variable. The present study investigated the effect of the SSRI paroxetine (4, 8, and 16 mg/kg, IP) in two tests of anxiety in mice: the light/dark test paradigm, and the four plates test (FPT). In both tests, it was found that paroxetine resulted in an anxiolytic-like effect at doses that did not modify motor performance (at the doses of 4 and 8 mg/kg in the light/dark test and at the doses of 4, 8, and 16 mg/kg in the four plates test). In the light/dark paradigm, both doses of buspirone significantly potentiated paroxetine, while in the four plates only one dose of buspirone (a 5HT(1A) partial agonist) (0.06 mg/kg) increased the anxiolytic-like effect of paroxetine. Prior administration of 1-PP was without effect in the light/dark paradigm but antagonized the effect of paroxetine (at the dose of 0.06 and 0. 5 mg/kg) in the FPT. The results suggested that a balance between pre- and postsynaptic 5-HT(1A) receptor was implicated in the anxiolytic-like effect of paroxetine. Buspirone seemed to emphasize the role of paroxetine in 5-HT(1A) receptor modulation and exerted a biphasic influence in the two tests.
机译：尽管研究抗焦虑药（ADs）时已经采用了许多动物方法，但急性给药后的结果仍存在很大差异。本研究调查了SSRI帕罗西汀（4、8和16 mg / kg，IP）在小鼠的两种焦虑测试中的作用：明/暗测试范例和四板测试（FPT）。在这两个试验中，发现帕罗西汀在不改变运动性能的剂量下（在明/暗试验中的剂量为4和8 mg / kg，在剂量为4，8，在四个平板的测试中为16 mg / kg）。在明/暗范式中，两种剂量的丁螺环酮均能显着增强帕罗西汀的浓度，而在四块板中，仅一种剂量的丁螺环酮（5HT（1A）部分激动剂）（0.06 mg / kg）可增强帕罗西汀的抗焦虑作用。先前施用1-PP在明/暗范式中无效，但拮抗了FPT中帕罗西汀的作用（剂量为0.06和0.5 mg / kg）。结果表明，突触前5-HT（1A）受体之间的平衡与帕罗西汀的抗焦虑作用有关。丁螺环酮似乎强调了帕罗西汀在5-HT（1A）受体调节中的作用，并在两个测试中产生了双相影响。

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