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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Strain differences in the anxiolytic effects of losartan in the mouse.
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Strain differences in the anxiolytic effects of losartan in the mouse.

机译：氯沙坦在小鼠中抗焦虑作用的菌株差异。

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摘要

Anxiolytic effects of the angiotensin AT(1) receptor antagonist losartan were studied in the elevated plus maze (EPM) and the light/dark test (LDT) in different mouse strains as were responses to angiotensin II and acetylcholine in isolated ascending colon. There were no significant strain differences in behaviour on the EPM, and diazepam was anxiolytic in C57BL/6, DBA/2 and BKW mice. Losartan was anxiolytic in BKW only. In the LDT, there were significant strain differences, with BKW mice exhibiting greatest anxiety-like behaviour; losartan was ineffective in this test. In vitro responses to angiotensin II and acetylcholine were significantly smaller in BKW than in C57BL/6 and DBA/2. These results indicate that the mouse strain exhibiting least angiotensin receptor function is the most responsive to the anxiolytic effects, suggesting a possible relationship between angiotensin receptor function and anxiolytic response to losartan.
机译：在不同的小鼠品系中，在高架迷宫（EPM）和明/暗测试（LDT）中研究了血管紧张素AT（1）受体拮抗剂洛沙坦的抗焦虑作用，以及对离体上升结肠中对血管紧张素II和乙酰胆碱的反应。 EPM上的行为无明显差异，地西differences在C57BL / 6，DBA / 2和BKW小鼠中具有抗焦虑作用。 Losartan仅在BKW中具有抗焦虑作用。在LDT中，存在显着的品系差异，BKW小鼠表现出最大的焦虑样行为。氯沙坦在该试验中无效。 BKW中对血管紧张素II和乙酰胆碱的体外反应明显小于C57BL / 6和DBA / 2。这些结果表明，表现出最少的血管紧张素受体功能的小鼠品系对抗焦虑作用最敏感，表明血管紧张素受体功能与对氯沙坦的抗焦虑反应之间可能存在关系。

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