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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >The 5-HT4 receptor antagonist, GR113808, reduces ethanol intake in alcohol-preferring rats.
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The 5-HT4 receptor antagonist, GR113808, reduces ethanol intake in alcohol-preferring rats.

机译：5-HT4受体拮抗剂GR113808可减少酒精偏爱大鼠的乙醇摄入量。

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摘要

The present study evaluated the effect of the selective 5-HT4 receptor antagonist, GR113808, on ethanol intake in alcohol-preferring rats. Rats were offered 10% ethanol 2 h/day. In the first experiment, rats had food and water ad lib and 10% ethanol was offered from 1800 to 2000 h. In the second experiment, food was freely available, 10% ethanol was offered 2 h/day, from 1800 to 2000 h, and water was offered for 4 h, from 1800 to 2200 h. In both experiments GR113808 was subcutaneously injected at doses of 1, 3, or 10 mg/kg for 4 consecutive days, 5 min before access to ethanol. From the first day of administration, GR113808 significantly reduced the volitional ethanol intake in water sated rats at the three doses tested. In water-deprived rats, it reduced ethanol intake at 3 and 10 mg/kg, without modifying total fluid and food intake. In both experiments the effect of GR113808 remained rather stable during the 4 days of administration. The present findings, showing that the 5-HT4 receptor antagonist, GR113808, selectively reduces ethanol intake in alcohol-preferring rats, suggest that 5-HT4 receptors may play a role in alcohol intake control.
机译：本研究评估了选择性5-HT4受体拮抗剂GR113808对酒精偏爱大鼠乙醇摄入的影响。每天2小时为大鼠提供10％乙醇。在第一个实验中，大鼠自由进食和饮水，并在1800至2000小时内提供10％的乙醇。在第二个实验中，免费提供食物，从1800至2000小时每天2小时提供10％的乙醇，从1800至2200小时每天提供4小时的水。在两个实验中，GR113808在获得乙醇之前5分钟连续1天，1、3或10 mg / kg的剂量皮下注射4天。从给药的第一天起，在三种受试剂量下，GR113808均可显着降低水充足大鼠的乙醇摄入量。在缺水的大鼠中，它以3和10 mg / kg的量减少了乙醇的摄入量，而没有改变总体液和食物的摄入量。在两个实验中，GR113808的作用在给药4天期间都保持稳定。本研究结果表明，5-HT4受体拮抗剂GR113808选择性降低了偏爱酒精的大鼠的乙醇摄入量，表明5-HT4受体可能在酒精摄入控制中起作用。

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