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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Assessment of motivational aspects involved in initiation of cocaine and heroin self-administration in rats.
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Assessment of motivational aspects involved in initiation of cocaine and heroin self-administration in rats.

机译：评估参与可卡因和海洛因自我管理大鼠的动机方面。

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摘要

A behavioral paradigm was explored to assess the motivational aspects involved in drug-taking behavior during initiation of drug self-administration. In separate saline-controlled experiments, naive animals were allowed to self-administer either cocaine or heroin (0.16 and 0.32 mg/kg per infusion) during five consecutive daily 3-h sessions by pressing one of two levers present in the test cage. During 15 min preceding the last four self-administration sessions, the animals had access to the levers but pressing the reinforcement lever did not result in a drug infusion. The animals properly self-administered both doses of cocaine and heroin, because the amount of self-infusions was higher than their saline control groups. Animals self-administering the high dose of cocaine and either dose of heroin performed lever-press behavior during the preceding period in a similar fashion as during the self-administration sessions, suggesting that this behavior during the preceding period was performed in the absence of the primary reinforcer, this behavior likely reflects the motivational state of animals to obtain the drug reinforcer, and thus may serve as a measure of the motivational aspects involved in the initiation of drug self-administration.
机译：探索了一种行为范式，以评估在药物自我管理启动过程中与吸毒行为有关的动机方面。在单独的盐水控制实验中，通过按测试笼中的两个控制杆之一，允许幼稚动物在连续五天的每天3小时内自我给予可卡因或海洛因（每次输注0.16和0.32 mg / kg）。在最后四次自我给药之前的15分钟内，动物可以使用控制杆，但按压增强控制杆不会导致药物输注。这些动物正确地自行服用了可卡因和海洛因，因为它们的自体输注量高于生理盐水对照组。自我给予高剂量可卡因和海洛因的动物在前一时期以与自我给药期间相似的方式进行了压杆行为，这表明前一时期的这种行为是在没有服用可卡因的情况下进行的。作为主要的补强剂，这种行为可能反映了动物获得补强剂的动机状态，因此可以作为参与药物自我管理的动机方面的量度。

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