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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Strain differences in the analgesic and reinforcing action of morphine in mice.
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Strain differences in the analgesic and reinforcing action of morphine in mice.

机译：吗啡在小鼠的镇痛和增强作用中的应变差异。

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摘要

The analgesic and reinforcing effects of morphine were compared in four strains of mice (C57BL/6, BALB/c, DBA, CBA). The analgesic action of morphine was measured in tail immersion (49 degrees C), hot plate (60 degrees C), and tail clip (four-point scale of nociceptive response) tests. The reinforcing action of morphine was studied in i.v. self-administration and conditioned place preference techniques. The results demonstrate strain differences in the analgesic and reinforcing action of morphine in mice. The relative rank order of the strains varied for the several tests as well as for the morphine effects. The lack of correlation between analgesic and reinforcing action of morphine in inbred strains supports the conclusion that analgesia and reinforcement are separate processes with different genetic control.
机译：比较了吗啡在四种小鼠品系（C57BL / 6，BALB / c，DBA，CBA）中的镇痛和增强作用。在尾巴浸入（49摄氏度），热板（60摄氏度）和尾夹（伤害反应的四分制）测试中测量了吗啡的镇痛作用。吗啡的补强作用在静脉内研究。自我管理和条件性位置偏爱技术。结果表明，吗啡在小鼠的镇痛和增强作用中存在应变差异。菌株的相对等级顺序在几个试验以及吗啡效应中有所不同。自交系吗啡的镇痛作用与增强作用之间缺乏相关性，这支持了以下结论：镇痛和增强作用是具有不同遗传控制的独立过程。

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