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首页> 外文期刊>Pharmacology and Toxicology: An International Journal >The mechanism underlying the protective effect of the thearubigin fraction of black tea (Camellia sinensis) extract against the neuromuscular blocking action of botulinum neurotoxins.
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The mechanism underlying the protective effect of the thearubigin fraction of black tea (Camellia sinensis) extract against the neuromuscular blocking action of botulinum neurotoxins.

机译：红茶茶花茶提取物茶树提取物级分对肉毒杆菌神经毒素的神经肌肉阻断作用的保护作用的机制。

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摘要

The aim of the present study was to elucidate the mechanism of the protective effect of black tea extract, the thearubigin fraction, against the neuromuscular blocking action of botulinum neurotoxin types A, B, and E. The effects of thearubigin fraction extracted from a black tea infusion were examined on the neuromuscular blocking action of botulinum neurotoxin types A, B, and E in mouse phrenic nerve-diaphragm preparations and on the binding of these toxins to rat cerebrocortical synaptosomes. Botulinum neurotoxin type A (1.5 nM), B (6 nM), or E (5 nM) abolished indirect twitches in mouse phrenic nerve-diaphragm preparations within 50, 90, 90 min., respectively. Thearubigin fraction mixed with each toxin blocked the inhibitory effect of the toxins. The specific binding of [125I]botulinum neurotoxin type A, B, or E to rat cerebrocortical synaptosomes was inhibited by mixing iodinated toxin with thearubigin fraction. The elution profile of [125I]botulinum neurotoxin type A, B, or E on Sephadex G-50 column chromatography was different from that of toxin mixed with thearubigin fraction. These findings indicate that thearubigin fraction protects against the neuromuscular blocking action of botulinum neurotoxin types A, B, and E by binding with the toxins.
机译：本研究的目的是阐明红茶提取物茶糖素组分对A，B和E型肉毒杆菌神经肌肉的神经肌肉阻滞作用的保护作用机理。从红茶中提取的茶红素组分的作用检查了输注对小鼠神经-制备物中A，B和E型肉毒杆菌神经毒素的神经肌肉阻滞作用，以及这些毒素与大鼠脑皮质突触体的结合情况。 A型肉毒杆菌神经毒素（1.5 nM），B型肉毒杆菌神经毒素（6 nM）或E（5 nM）分别在50、90、90分钟内消除了小鼠神经隔膜制剂中的间接抽搐。与每种毒素混合的花红素级分阻断了毒素的抑制作用。通过将碘化毒素与茶红素级分混合，可以抑制A，B或E型[125I]肉毒杆菌神经毒素与大鼠脑皮质突触体的特异性结合。在Sephadex G-50柱色谱上，A，B或E型[125I]肉毒杆菌神经毒素的洗脱曲线与混有thearubigin组分的毒素的洗脱曲线不同。这些发现表明，茶红素级分通过与毒素结合而保护免受A，B和E型肉毒杆菌神经毒素的神经肌肉阻滞作用。

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