• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Adult vs. adolescent rats differ in biobehavioral responses to chronic nicotine administration.
【24h】

Adult vs. adolescent rats differ in biobehavioral responses to chronic nicotine administration.

机译：成年与青春期大鼠对慢性尼古丁给药的生物行为反应有所不同。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

More than 90% of smokers begin smoking during adolescence, suggesting that nicotine's actions may differ in adults vs. adolescents in ways that render adolescents vulnerable to smoking initiation. This experiment tested the hypothesis that nicotine's biobehavioral actions differ in adult and adolescent rats. Forty-two male (21 adolescents, 21 adults) and 41 female (21 adolescents, 20 adults) Sprague-Dawley rats were administered saline or 12 mg/kg/day nicotine via osmotic minipump for 21 days. Body weight, feeding, and locomotion (horizontal activity, vertical activity, center time) were measured before, during, and after saline or nicotine administration. Nicotine's effects depended on age and sex. Nicotine reduced body weight and feeding of adult males and females, and of adolescent males, but not of adolescent females. In addition, adolescent males were more sensitive than adults or adolescent females to nicotine's activity-enhancing effects. In cessation, nicotine-exposed adolescent males continued to exhibit greater activity than saline-exposed animals. Results indicate that nicotine's biobehavioral actions differ depending on age and sex.
机译：超过90％的吸烟者在青春期开始吸烟，这表明在成年人和青少年中尼古丁的行为可能有所不同，从而使青少年容易受到吸烟的影响。该实验检验了在成年和青春期大鼠中尼古丁的生物行为不同的假设。雄性Sprague-Dawley大鼠42只（21名青少年，21名成人）和41名雌性（21名青少年，20名成人）通过渗透性微型泵给予生理盐水或12 mg / kg /天的尼古丁，持续21天。在施用盐或尼古丁之前，之中和之后测量体重，进食和运动（水平活动，垂直活动，中心时间）。尼古丁的影响取决于年龄和性别。尼古丁降低了成年雄性和雌性以及青春期雄性的体重和喂养，但未降低青春期雌性的体重。此外，青春期男性对尼古丁的活动增强作用比成年人或青春期女性敏感。戒烟后，暴露于尼古丁的青春期男性继续表现出比暴露于盐水的动物更大的活性。结果表明，尼古丁的生物行为取决于年龄和性别。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号