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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effects of chronic methamphetamine on SCH23390- or haloperidol-induced catalepsy, and effects of coadministration of SCH23390 or haloperidol in mice.
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Effects of chronic methamphetamine on SCH23390- or haloperidol-induced catalepsy, and effects of coadministration of SCH23390 or haloperidol in mice.

机译：慢性冰毒对小鼠SCH23390或氟哌啶醇诱导的僵直症的影响以及SCH23390或氟哌啶醇的共同给药对小鼠的影响。

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摘要

The influence of chronic treatment of mice with methamphetamine, an indirect dopamine agonist, on the cataleptic effects of R-(+)-chloro-2,3,4,5,-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin -7ol hydrochloride (SCH23390), a D1 receptor agonist, or haloperidol, a mainly D2 antagonist, was investigated. Once every other day treatment with 3 mg/kg SC methamphetamine for 15 days resulted in an increase in the catalepsy produced by haloperidol (0.3 mg/kg IP) (haloperidol catalepsy), but in a decrease in the catalepsy produced by SCH23390 (0.3 mg/kg IP) (SCH23390 catalepsy), 24 h and 7 days after withdrawal of methamphetamine. These effects of chronic methamphetamine were antagonized by coadministration of either SCH23390 (0.5 mg/kg SC) or haloperidol (1.0 mg/kg SC). These results suggest that the decreased responsiveness to SCH23390 in chronic methamphetamine-pretreated mice results from a supersensitivity of D1 receptors, and that the increased responsiveness to haloperidol catalepsy results from a subsensitivity of D2 receptors. The attenuated response to SCH23390 may be interpreted as an example of sensitization to methamphetamine, and the enhanced haloperidol response as an example of tolerance to methamphetamine, based on the development of supersensitivity and subsensitivity of D1 and D2 receptors, respectively, after chronic methamphetamine administration. Furthermore, it is suggested that coadministration of either SCH23390 or haloperidol could prevent the development of D1 receptor supersensitivity and D2 receptor subsensitivity induced by chronic methamphetamine.
机译：间接多巴胺激动剂甲基苯丙胺对小鼠的慢性治疗对R-（+）-氯-2,3,4,5，-四氢-3-甲基-5-苯基-1H-3的致敏作用的影响研究了D1受体激动剂-benzazepin -7ol盐酸盐（SCH23390），或主要是D2拮抗剂氟哌啶醇。每隔一天用3 mg / kg SC甲基苯丙胺治疗15天，导致氟哌啶醇（0.3 mg / kg腹膜内注射）引起的僵住症增加（氟哌啶醇僵直），但SCH23390（0.3 mg / kg IP）（SCH23390僵直），停用甲基苯丙胺后24小时和7天。 SCH23390（0.5 mg / kg SC）或氟哌啶醇（1.0 mg / kg SC）的共同给药可拮抗慢性甲基苯丙胺的这些作用。这些结果表明，慢性甲基苯丙胺预处理的小鼠对SCH23390的响应性降低是由于D1受体的超敏性引起的，而对氟哌啶醇僵直症的响应性增强是由D2受体的超敏性引起的。分别基于D1和D2受体在长期服用甲基苯丙胺后的超敏性和亚敏性的发展，对SCH23390的减弱应答可解释为对甲基苯丙胺致敏的实例，而氟哌啶醇应答的增强可解释为对甲基苯丙胺的耐受性。此外，有人建议同时服用SCH23390或氟哌啶醇可以预防慢性甲基苯丙胺引起的D1受体超敏和D2受体亚敏的发展。

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