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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >MK801 increases feeding and decreases drinking in nondeprived, freely feeding rats.
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MK801 increases feeding and decreases drinking in nondeprived, freely feeding rats.

机译：MK801可增加非剥夺性自由喂养大鼠的摄食量并减少其饮水量。

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摘要

The noncompetitive NMDA receptor antagonist MK801 has been reported to increase food intake in rats during scheduled test meals of palatable foods or after food deprivation, but not in nondeprived rats given rodent chow. To determine if MK801 has an effect on spontaneous meals, MK801 (100 microg/kg) was administered 15 min prior to dark onset to nondeprived rats maintained on powdered rodent chow, and spontaneous food and water access was measured. MK801 increased the length of the first meal and the amount of time spent feeding within the meal. Conversely, MK801 decreased the length and size of the first drinking bout. MK801 did not alter the latency to the first meal or drinking bout, nor the intervals between successive meals or bouts. The effects of MK801 on feeding and drinking bouts were partially confirmed by measuring total chow and water intake over the first 2 h of the dark period. Thus, acute MK801 can significantly alter spontaneous chow feeding and drinking in nondeprived rats when administered prior to dark onset.
机译：据报道，非竞争性NMDA受体拮抗剂MK801可以在预定的可口食物测试餐期间或食物剥夺后增加大鼠的食物摄入量，但在没有啮齿动物食物的非剥夺大鼠中则不能增加食物摄入。为了确定MK801是否对自发餐产生影响，在黑暗发作前15分钟将MK801（100微克/千克）施用于保持粉状啮齿动物食物的非剥夺大鼠，并测量其自发食物和水的摄入量。 MK801增加了第一顿饭的时间和进餐时间。相反，MK801减少了第一次饮水次数的长度和大小。 MK801不会改变第一次进餐或饮酒的潜伏期，也不会改变连续进餐或饮酒之间的间隔。 MK801对摄食和饮水发作的影响通过在黑暗时段的前2小时内测量总食物和摄水量得到了部分确认。因此，急性发作前夕给药时，急性MK801可以显着改变未剥夺大鼠的自发性食物。

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