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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Immediate and delayed voluntary ethanol effects on motor performance, learning and inhibition in rats.
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Immediate and delayed voluntary ethanol effects on motor performance, learning and inhibition in rats.

机译：立即和延迟的自愿性乙醇对大鼠运动表现，学习和抑制的影响。

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The effects of prolonged voluntary ethanol consumption on psychomotor performance, operant conditioning and inhibition were examined in adult male Wistar rats. Animals were food deprived and alcohol or control solution was available 1 h/day during 15 days, with free water for the rest of the day. Then, rats were tested in a two-bottle paradigm (solution and water available) for 1 h/day during 19 days, and subjects were tested daily for psychomotor performance and operant conditioning immediately or 6 h after (delayed) the solution access. Psychomotor performance was tested in an 80 degrees -inclined screen. Successive conditioning phases were: free shaping (FS), continuous reinforcement (CRF), operant extinction (EXT), successive discrimination (DIS) and two-stimuli test (TST). Alcohol consumption deteriorated psychomotor performance and improved the animal's ability to learn simple associations between stimuli and responses (free shaping and extinction), in immediate and delayed groups. Finally, alcohol deteriorated behavioral inhibition (DIS and TST) tested immediately after drinking. Taken together, results suggest that prolonged voluntary ethanol intake could induce permanent psychomotor impairment and associative learning facilitation, and also an impairment of the inhibition related to the intoxication state.
机译：在成年雄性Wistar大鼠中检查了长期自愿摄入乙醇对精神运动表现，操作条件和抑制的影响。剥夺动物的食物，在15天之内每天1小时提供酒精或对照溶液，并在一天的剩余时间内提供免费水。然后，在19天之内以两瓶范式（大鼠可用水和溶液）对大鼠进行1小时/天的测试，每天或在（延迟）溶液进入（延迟）后6小时，每天对受试者的精神运动表现和手术条件进行测试。在80度倾斜的屏幕中测试了精神运动性能。连续的调理阶段为：自由塑形（FS），连续增强（CRF），手术消光（EXT），连续鉴别（DIS）和两次刺激试验（TST）。饮酒会降低精神运动能力，并改善动物在即刻和延迟组中学习刺激与反应（自由塑形和灭绝）之间简单关联的能力。最后，饮酒后立即测试酒精会使行为抑制（DIS和TST）恶化。两者合计，结果表明，长时间自愿摄入乙醇会诱发永久性精神运动障碍和联想学习促进，以及与中毒状态有关的抑制作用障碍。

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