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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Central administration of mCPP, a serotonin 5-HT(2B/2C) agonist, decreases water intake in rats.
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Central administration of mCPP, a serotonin 5-HT(2B/2C) agonist, decreases water intake in rats.

机译：中央给药5-羟色胺5-HT（2B / 2C）激动剂mCPP可减少大鼠的饮水量。

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摘要

In the present study, we investigated in rats the effect of third ventricle injections of 1-(3-chlorophenyl)piperazine (mCPP), a 5-HT(2) receptor agonist, on water intake induced by three different physiological stimuli: fluid deprivation, acute salt load and hypovolemia. Injections of mCPP in the doses of 80 and 160 nmol/rat were able to decrease water intake in all three conditions studied. Third ventricle injections of mCPP (160 nmol/rat) were no longer able to diminish water intake in the groups of rats pretreated with central injections of an equimolar amount of (+)-cis-4,5,7a,8,9,10,11,11a-octahydro-7H-10-methylindolo[1,7-bc][2,6]-nap hthyridine (SDZ SER 082), a selective 5-HT(2B/2C) antagonist. The central administration of mCPP (160 nmol/rat) was not able to modify the intake of a 0.1% saccharin solution. It is suggested that the central activation of a 5-HT(2B/2C) component is able to impair the drive for water intake induced by the physiological stimuli represented by fluid deprivation, acute salt load and hypovolemia. This effect seems not to be consequent on a general nonspecific central nervous system depression or on a locomotor deficit, because saccharin intake is not affected by third ventricle injections of mCPP.
机译：在本研究中，我们研究了大鼠的第三次心室注射1-（3-氯苯基）哌嗪（mCPP），5-HT（2）受体激动剂对三种不同生理刺激引起的摄水的影响：水分剥夺，急性盐负荷和血容量不足。在所研究的所有三种情况下，以80和160 nmol /大鼠的剂量注射mCPP都能减少水的摄入。在以等摩尔量（+）-顺式-4,5,7a，8,9,10进行中央注射预处理的大鼠组中，第三次心室注射mCPP（160 nmol /大鼠）不再能够减少水的摄入选择性的5-HT（2B / 2C）拮抗剂，11,11a-八氢-7H-10-甲基吲哚并[1,7-bc] [2,6]-萘啶（SDZ SER 082）。 mCPP（160 nmol /大鼠）的中央给药不能改变0.1％糖精溶液的摄入量。建议5-HT（2B / 2C）组件的中央激活能够削弱由缺水，急性食盐负荷和血容量不足代表的生理刺激引起的水摄入驱动力。似乎对一般的非特异性中枢神经系统抑制或运动功能不全没有结果，因为糖精的摄入不受mCPP第三脑室注射的影响。

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