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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Acquisition and expression of conditioned hypoalgesia in morphine-naive and morphine-tolerant rats.
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Acquisition and expression of conditioned hypoalgesia in morphine-naive and morphine-tolerant rats.

机译：在未接受吗啡和耐受吗啡的大鼠中条件性痛觉过敏的获取和表达。

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摘要

The present study used a within-subject design to examine acquisition and expression of conditioned hypoalgesia in 50 male Wistar rats. Morphine-naive rats preexposed to a heat stressor with saline were hypoalgesic when subsequently tested for latencies to tail flick or paw lick. However, morphine-tolerant rats preexposed to the heat stressor with saline failed to display hypoalgesia when tested for latencies to tail flick, but showed hypoalgesia when tested for latencies to paw lick. Taken together, these findings suggest that expression of conditioned hypoalgesic responses in morphine-tolerant rats may depend on the nociceptive test used. Both morphine-naive and morphine-tolerant rats preexposed to the heat stressor with morphine failed to display hypoalgesia on either the tail-flick or the hot-plate test, demonstrating that morphine's ability to block acquisition of conditioned hypoalgesia is independent of the test used to assess nociceptive sensitivity.
机译：本研究使用受试者内部设计检查了50只雄性Wistar大鼠的条件性痛觉过敏的获取和表达。预先暴露于热刺激下并加盐水的吗啡幼稚大鼠在随后测试甩尾或舔爪的潜伏期时具有镇痛作用。但是，预先暴露于热应激下并加盐水的吗啡耐受大鼠在测试甩尾潜伏期时未显示出痛觉过敏，但在测试了舔舔潜伏期时显示出了痛觉过敏。综上所述，这些发现表明吗啡耐受大鼠中条件性痛觉过敏反应的表达可能取决于所使用的伤害性测试。暴露于吗啡的热应激源的未接受吗啡的大鼠和接受吗啡耐受的大鼠在甩尾或热板试验中均未显示出痛觉过敏，表明吗啡阻断条件性痛觉过敏的能力独立于用于评估伤害感受敏感性。

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