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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Behavioral effects and anatomic correlates after brain injury: a progesterone dose-response study.
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Behavioral effects and anatomic correlates after brain injury: a progesterone dose-response study.

机译：脑损伤后的行为效应和解剖学相关性：孕激素剂量反应研究。

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Evidence suggests that progesterone enhances functional recovery in rats after medial frontal cortical contusions; however, a high dose of progesterone exacerbates tissue loss in a stroke model when administered chronically (7-10 days) prior to injury [Stroke 31 (2000) 1173)]. This study attempts to determine progesterone's dose-response effects on behavioral performance and GABA-A receptor expression following a cortical contusion. Male rats received injections of 0, 8, 16, or 32 mg/kg progesterone in 22.5% 2-hydroxypropyl-beta-cyclodextrin following cortical impact. Lesion 8 mg/kg and lesion 16 mg/kg groups displayed less thigmotaxis in the Morris water maze (MWM) than 0 and 32 mg/kg groups and were not significantly impaired relative to shams on other water maze measures. Increased variability in the 32 mg/kg group during somatosensory neglect testing was the only evidence indicating that a high dose of progesterone was disruptive to a few animals. These results suggest that low and moderate doses of progesterone are optimal for facilitating recovery of select behaviors and that postinjury progesterone treatment permits a wider dose range than preinjury treatment. Progesterone did not affect lesion size, but a strong negative correlation was observed between thalamic GABA-A receptor density and water maze performance. Future studies could explore causes for this relationship.
机译：有证据表明，孕酮可增强大鼠内侧额叶皮质挫伤后的功能恢复。但是，在受伤前长期（7-10天）给药时，高剂量的孕酮会加剧中风模型的组织损失[Stroke 31（2000）1173）]。这项研究试图确定黄体酮对皮质挫伤后行为表现和GABA-A受体表达的剂量反应影响。皮层撞击后，雄性大鼠接受22.5％2-羟丙基-β-环糊精注射0、8、16或32 mg / kg孕酮。病变8 mg / kg组和病变16 mg / kg组在莫里斯水迷宫（MWM）中显示出的触变性比0和32 mg / kg组少，并且相对于其他水迷宫措施中的not毛而言，受损不明显。体感疏忽试验期间32 mg / kg组的变异性增加是唯一表明高剂量孕酮对少数动物具有破坏性的证据。这些结果表明，低剂量和中等剂量的孕酮对于促进特定行为的恢复是最佳的，并且损伤后的孕酮治疗比损伤前的治疗允许更大的剂量范围。孕酮不影响病变的大小，但丘脑GABA-A受体密度与水迷宫性能之间存在强烈的负相关性。未来的研究可能会探讨这种关系的原因。

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