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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Changes in behavior and monoamine levels in microdialysate from dorsal striatum after 6-OHDA infusions into ventral striatum.
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Changes in behavior and monoamine levels in microdialysate from dorsal striatum after 6-OHDA infusions into ventral striatum.

机译：6-OHDA注入腹侧纹状体后，背侧纹状体微透析液中行为和单胺水平的变化。

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Long-Evans rats received bilateral 6-hydroxydopamine infusions into the nucleus accumbens and were tested immediately (1 and 2 days) or after a recovery period (14 and 15 days) for changes in extracellular levels of dorsal striatal monoamines using in vivo microdialysis. Compared to controls, the monoamine metabolites 3,4-dihydroxyphenylacetic acid, homovanillic acid and 5-hydroxyindoleacetic acid were generally enhanced when tested immediately after 6-hydroxydopamine treatment, including spontaneous levels and those following depolarizing infusions of potassium (60 mM, 20 min) through the microdialysis probes. Following 2 weeks recovery, dopamine metabolite levels were depressed and the serotonin metabolite levels remained enhanced. D-Amphetamine sulfate (1.5 mg/kg, SC) stimulated dopamine overflow was enhanced 2 days after 6-hydroxydopamine administration, but not after 2 weeks recovery. In contrast, potassium increased dopamine overflow to the same extent as control animals regardless of recovery period following 6-hydroxydopamine. The immediate changes in striatal monoamine activity were accompanied by a potentiation of amphetamine-induced stereotyped behaviors. We suggest that transient presynaptic changes within the dorsal striatum following disruption of the ventral striatum may mediate some general aspects of loss and recovery of behavior related to the time course of 6-hydroxydopamine neurotoxicity.
机译：Long-Evans大鼠接受双侧6-羟基多巴胺输注到伏隔核中，并立即（1和2天）或恢复期（14和15天）后使用体内微透析测试了背纹状体单胺的细胞外水平变化。与对照相比，在6-羟基多巴胺处理后立即进行检测时，单胺代谢物3,4-二羟基苯基乙酸，高香草酸和5-羟基吲哚乙酸通常会增强，包括自发水平和去极化输注钾后的水平（60 mM，20分钟）通过微透析探针。恢复2周后，多巴胺代谢物水平降低，而血清素代谢物水平保持升高。施用D-苯丙胺（1.5 mg / kg，SC）刺激的多巴胺溢流在施用6-羟基多巴胺后2天有所增强，但在恢复2周后并未增强。相反，无论6-羟基多巴胺的恢复期如何，钾均会增加多巴胺溢流至与对照动物相同的程度。纹状体单胺活性的立即变化伴随着苯丙胺诱导的刻板行为的增强。我们建议，腹侧纹状体破裂后，背侧纹状体内的突触前突触变化可能介导一些与6-羟基多巴胺神经毒性时间过程有关的行为丧失和恢复的一般方面。

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