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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effects of naltrexone and isradipine, alone or in combination, on cocaine responses in humans.
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Effects of naltrexone and isradipine, alone or in combination, on cocaine responses in humans.

机译：纳曲酮和伊拉地平单独或组合对人类可卡因反应的影响。

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Preclinical studies suggested that combination of naltrexone and isradipine may be useful for the treatment of cocaine addiction. This study examined whether naltrexone and isradipine, alone or in combination, would attenuate the subjective and physiological effects of cocaine in humans. Seven cocaine users participated in a randomized, double-blind, placebo-controlled inpatient study. Before each of the seven experimental sessions, subjects were treated orally with naltrexone (50 mg or placebo), isradipine (10 mg or placebo), or naltrexone plus isradipine. Subjects then received a single dose of intranasal cocaine (4 mg or 100 mg/70 kg). Isradipine alone attenuated the systolic blood pressure response to cocaine. In contrast, isradipine plus naltrexone treatment attenuated both the systolic and diastolic blood pressure responses. Naltrexone alone did not affect the blood pressure response to cocaine. For subjective response to cocaine, isradipine, alone or in combination with naltrexone, did not have significant effects. Naltrexone treatment alone attenuated the rating of "good effects" from cocaine without affecting other subjective responses. These results suggest that isradipine alone or in combination with naltrexone attenuates some of the physiological effects of cocaine.
机译：临床前研究表明，将纳曲酮和异拉地平联合使用可能可用于治疗可卡因成瘾。这项研究检查了纳曲酮和异地平单独或联合使用是否会减弱可卡因对人的主观和生理作用。七名可卡因使用者参加了一项随机，双盲，安慰剂对照的住院研究。在七个实验阶段的每一个之前，对受试者口服纳曲酮（50 mg或安慰剂），异拉地平（10 mg或安慰剂）或纳曲酮加异拉平进行口服治疗。然后受试者接受单剂量的鼻内可卡因（4 mg或100 mg / 70 kg）。单独使用伊拉地平可减轻对可卡因的收缩压反应。相反，伊拉地平加纳曲酮治疗可减弱收缩压和舒张压反应。单独使用纳曲酮不会影响对可卡因的血压反应。对于可卡因的主观反应，单独或与纳曲酮联用的伊拉地平没有明显的作用。单独使用纳曲酮治疗可卡因在不影响其他主观反应的情况下减弱了“良好效果”的等级。这些结果表明，单独使用伊拉地平或与纳曲酮联用会减弱可卡因的某些生理作用。

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