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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Amantadine does not modulate reinforcing, subjective, or cardiovascular effects of cocaine in humans.
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Amantadine does not modulate reinforcing, subjective, or cardiovascular effects of cocaine in humans.

机译：金刚烷胺不调节可卡因对人的增强，主观或心血管作用。

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摘要

Data from several clinical studies have suggested that amantadine, which has dopaminergic agonist and glutamatergic antagonist effects, may be useful for the treatment of cocaine dependence. The interaction between amantadine and smoked cocaine was examined in 10 cocaine smokers (7 men, 3 women), who participated in a 26-day inpatient study. Participants were maintained on amantadine (0 and 100 mg bid) for 5 days prior to laboratory testing, using a double-blind crossover design. Under each medication condition, participants smoked a sample dose of cocaine base (0, 12, 25, and 50 mg) once, and were subsequently given five choice opportunities, 14 min apart, to self-administer that dose of cocaine or receive a merchandise voucher (Dollars 5.00). Each cocaine dose was tested twice under each medication condition, and the order of medication condition and cocaine dose varied systematically. Cocaine produced stimulant-like reinforcing, subjective, and physiological effects. Amantadine maintenance did not modify the choice to self-administer smoked cocaine. These findings, taken together with the decidedly mixed literature, suggest that amantadine (100 mg bid) will not have a role in the treatment of cocaine dependence.
机译：来自数项临床研究的数据表明，具有多巴胺能激动剂和谷氨酸能拮抗剂作用的金刚烷胺可用于治疗可卡因依赖性。参加了为期26天的住院研究的10名可卡因吸烟者（7名男性，3名女性）检查了金刚烷胺与可卡因的相互作用。使用双盲交叉设计，在实验室测试之前，将参与者维持在金刚烷胺（0和100 mg bid）上5天。在每种用药条件下，参与者抽烟一次样品剂量的可卡因碱（0、12、25和50 mg），然后给予五次选择机会，相距14分钟，以自我管理该剂量的可卡因或接受商品优惠券（美元5.00）。每个可卡因剂量在每种用药条件下均测试两次，用药条件和可卡因剂量的顺序系统地变化。可卡因产生兴奋剂样的增强，主观和生理作用。金刚烷胺维持治疗并没有改变烟熏可卡因自我管理的选择。这些发现以及完全混合的文献表明，金刚烷胺（100 mg bid）在可卡因依赖性治疗中不起作用。

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