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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Involvement of the sigma(1) receptor in the motivational effects of ethanol in mice.
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Involvement of the sigma(1) receptor in the motivational effects of ethanol in mice.

机译：sigma（1）受体参与乙醇对小鼠的激励作用。

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摘要

In the present study, we examined the involvement of the sigma(1) (sigma(1)) receptor in several behavioral manifestations of ethanol addiction. Administration of ethanol (0.5, 1, and 2 g/kg) in Swiss mice dose-dependently induced locomotor stimulation, conditioned place preference, and conditioned taste aversion, which are considered as behavioral index of drug-induced reward. Pretreatment with the selective sigma(1) receptor antagonist N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(dimethylamino)ethylamine (BD1047, 3-30 mg/kg) dose-dependently blocked ethanol (1 g/kg)-induced hyperlocomotion and taste aversion and ethanol (2 g/kg)-induced place preference. Pretreatment with the selective sigma(1) receptor agonist 2-(4-morpholino)ethyl 1-phenylcyclohexane-1-carboxylate (PRE-084, 1-10 mg/kg) before ethanol (0.5 g/kg) failed to affect the resulting locomotor stimulation, but dose-dependently enhanced the conditioned place preference. Each sigma(1) receptor ligand was devoid of behavioral effect by itself. These observations show that activation of the sigma(1) receptor is a necessary component of ethanol-induced motivational effects and suggest a new pharmacological target for alleviating ethanol addiction.
机译：在本研究中，我们检查了sigma（1）（sigma（1））受体参与乙醇成瘾的几种行为表现。在瑞士小鼠中给予乙醇（0.5、1和2 g / kg）剂量依赖性地引起运动刺激，条件性位置偏爱和条件性味觉厌恶，它们被视为药物诱导的奖励的行为指标。用选择性sigma（1）受体拮抗剂N- [2-（3,4-二氯苯基）乙基] -N-甲基-2-（二甲基氨基）乙胺（BD1047，3-30 mg / kg）进行剂量依赖性阻断的乙醇预处理（1 g / kg）引起的过度运动和口味厌恶，以及乙醇（2 g / kg）引起的位置偏好。在乙醇（0.5 g / kg）不能影响生成物之前，用选择性sigma（1）受体激动剂2-（4-吗啉代）乙基1-苯基环己烷-1-甲酸（PRE-084，1-10 mg / kg）进行预处理运动刺激，但剂量依赖性地增加了条件场所的偏好。每个sigma（1）受体配体本身没有行为影响。这些观察结果表明，激活sigma（1）受体是乙醇诱导的动机作用的必要组成部分，并提出了减轻乙醇成瘾的新药理学靶标。

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