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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Neurosteroid consumption has anxiolytic effects in mice.
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Neurosteroid consumption has anxiolytic effects in mice.

机译：食用神经类固醇对小鼠具有抗焦虑作用。

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The neurosteroids allopregnanolone (ALLOP) and pregnanolone (PREG), like ethanol, potentiate gamma-aminobutyric acid(A) receptor function. PREG-hemisuccinate (PREG-HS) is a negative modulator of N-methyl-D-aspartate (NMDA) receptors. Because C57BL/6J (B6) and DBA/2J (D2) mice differ in ethanol preference, voluntary consumption of ALLOP and PREG-HS (50 microg/ml solution) versus tap water was measured in B6 and D2 mice for a minimum of 8 days. Mice were acclimated to a reverse light-dark cycle prior to the initiation of experiments. In the first study, both B6 and D2 mice exhibited preference for the PREG-HS solution. In the second study, neither strain exhibited significant preference for the ALLOP solution versus water. However, the ALLOP-consuming B6 and D2 mice exhibited significant anxiolysis when they were tested on the elevated plus maze following 8 days of ALLOP consumption, compared to separate animals that consumed only water. A subsequent study determined that systemic administration of PREG-HS had significant anxiolytic effects in both B6 and D2 mice, when assessed on the elevated plus maze. Plasma ALLOP levels in the steroid-consuming mice from both studies were significantly increased versus basal levels only in the D2 strain. While the pattern of steroid intake or strain differences in steroid conversion may have influenced the differential change in plasma ALLOP levels, it is noteworthy that both strains consumed doses of ALLOP, and presumably doses of PREG-HS, that were anxiolytic.
机译：像乙醇一样，神经甾体Allopregnanolone（ALLOP）和pregnanolone（PREG）可以增强γ-氨基丁酸（A）受体的功能。 PREG-半琥珀酸酯（PREG-HS）是N-甲基-D-天冬氨酸（NMDA）受体的负调节剂。由于C57BL / 6J（B6）和DBA / 2J（D2）小鼠在乙醇偏爱方面有所不同，因此在B6和D2小鼠中测得的自来水相对于自来水的ALLOP和PREG-HS（50微克/毫升溶液）的自愿摄入量至少为8天。在实验开始之前，使小鼠适应反向的明暗循环。在第一个研究中，B6和D2小鼠均表现出对PREG-HS溶液的偏爱。在第二项研究中，两种菌株都没有表现出比水更显着的ALLOP溶液。但是，与仅喝水的单独动物相比，消耗ALLOP的B6和D2小鼠在消耗ALLOP 8天后在高架加迷宫中进行测试时表现出明显的抗焦虑作用。随后的一项研究确定，在高架迷宫中评估时，全身施用PREG-HS对B6和D2小鼠均具有显着的抗焦虑作用。与仅在D2品系中的基础水平相比，两项研究中消耗类固醇的小鼠的血浆ALLOP水平均显着增加。尽管类固醇摄入的方式或类固醇转化的菌株差异可能已影响血浆ALLOP水平的差异变化，但值得注意的是，这两种菌株均消耗了抗焦虑药ALLOP和PREG-HS剂量。

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