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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effects of morphine or naloxone on cocaine-induced genital reflexes in paradoxical sleep-deprived rats.
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Effects of morphine or naloxone on cocaine-induced genital reflexes in paradoxical sleep-deprived rats.

机译：吗啡或纳洛酮对可卡因诱发的自相矛盾睡眠剥夺大鼠生殖器反射的影响。

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摘要

The involvement of opioidergic neurotransmission in the modulation of genital reflexes induced by paradoxical sleep deprivation (PSD) and cocaine in rats was the aim of the present study. Morphine (0, 1, 5 and 10 mg/kg) and naloxone (0, 0.3, 3 and 30 mg/kg) were administered prior to saline or cocaine to rats that had been deprived of sleep and the incidence of penile erections (PE) and ejaculations (EJ) was measured. PSD alone induced PE in 50% and EJ in 20% of the rats, but these behaviors were not influenced by morphine or naloxone. Cocaine potentiated the incidence of genital reflexes in PSD rats to 90% (PE) and 70% (EJ). Morphine and not naloxone significantly reduced the percentage of rats displaying this response at the highest doses. Morphine also significantly reduced PE and EJ frequencies at 10 mg/kg. Furthermore, this inhibitory effect of morphine on genital reflexes was prevented by the prior injection of naloxone. Although a number of factors are involved in such a complex phenomenon as PEand EJ, our data show that activation of the opioidergic systems by the agonist morphine reduces genital reflexes-induced by cocaine in PSD males while the antagonist, naloxone, did not have any significant effect. The findings suggest that the stimulating effects of cocaine in potentiating genital reflexes in PSD rats can be unidirectionally modified by opioidergic systems.
机译：本研究的目的是在大鼠自相矛盾的睡眠剥夺（PSD）和可卡因引起的生殖器反射的调节中涉及视皮层神经传递。在生理盐水或可卡因之前，先将吗啡（0、1、5、10和10 mg / kg）和纳洛酮（0、0.3、3和30 mg / kg）施用于那些缺乏睡眠和阴茎勃起（PE）的大鼠）和射精（EJ）。单独的PSD引起50％的大鼠PE和20％的EJ，但是这些行为不受吗啡或纳洛酮的影响。可卡因可将PSD大鼠生殖器反射的发生率提高到90％（PE）和70％（EJ）。吗啡而不是纳洛酮显着降低了在最高剂量下表现出这种反应的大鼠的百分比。吗啡在10 mg / kg时也显着降低PE和EJ频率。此外，事先注射纳洛酮可防止吗啡对生殖器反射的这种抑制作用。尽管许多因素都参与了诸如PE和EJ这样的复杂现象，但我们的数据显示，吗啡激动剂激活吗啡能神经系统降低了可卡因在PSD男性中引起的生殖器反射，而拮抗剂纳洛酮没有明显意义。影响。这些发现表明，可卡因对增强PSD大鼠生殖器反射的刺激作用可通过阿片体能系统单向改变。

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