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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Buprenorphine increases intake of freely available and operant-contingent food in satiated rats.
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Buprenorphine increases intake of freely available and operant-contingent food in satiated rats.

机译：丁丙诺啡可增加饱足大鼠的游离和操作性食物的摄入量。

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摘要

Opiate administration increases short-term free feeding in satiated rats. The feeding effects of the mixed opioid receptor agonist/antagonist buprenorphine were examined in both free-feeding and operant chamber paradigms. Buprenorphine (0.1 and 0.3 mg/kg) produced significant increases in short-term free feeding (i.e., 4 h), an effect enhanced by repeated administration. Buprenorphine's effects on operant responding were examined in satiated rats using a fixed ratio (FR) 80 (initial pellet) FR 3 (subsequent pellets) reinforcement schedule. Buprenorphine (0.03-0.3 mg/kg) decreased latency to begin responding for food, and increased total number of pellets consumed in a 1-h session. Increases in food intake relative to control were caused by continued responding for food as sessions progressed. Naloxone suppressed both the free-feeding and operant-contingent intake induced by buprenorphine. Thus, buprenorphine increases both freely available and lever-press contingent food intake.
机译：阿片类药物的施用增加了饱足大鼠的短期自由进食。在自由进食和手术室范式中都检查了混合的阿片受体激动剂/拮抗剂丁丙诺啡的进食效果。丁丙诺啡（0.1和0.3 mg / kg）在短期免费喂食（即4小时）中产生显着增加，通过重复给药可增强这种作用。使用固定比例（FR）80（初始药丸）FR 3（随后的药丸）强化方案，在饱足大鼠中检查丁丙诺啡对手术反应的影响。丁丙诺啡（0.03-0.3 mg / kg）减少了开始对食物做出反应的潜伏期，并增加了在1小时内消耗的药丸总数。与节食有关的食物摄入量增加是由于随着会议的进行对食物的持续反应而引起的。纳洛酮抑制丁丙诺啡引起的自由进食和操作性摄食。因此，丁丙诺啡增加了可自由利用的食物和杠杆式或有食物的摄入量。

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