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7-OH-DPAT injected into the accumbens reduces locomotion and sucrose ingestion: D3 autoreceptor-mediated effects?

机译:将7-OH-DPAT注射到伏隔肌中可减少运动和蔗糖摄入:D3受体介导的作用?

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摘要

7-hydroxy-N,N-di-n-propyl-2-aminotetralin (7-OH-DPAT) injected bilaterally in the nucleus accumbens (NAC) resulted in profound, noncatatonic, dose-dependent (0.3-3 mg total dose) hypolocomotion but without inducing yawning. It also decreased intake of a highly preferred 3% sucrose solution (1 microgram total dose). Systemic injection of 7-OH-DPAT (0.1-3.0 mg/kg, i.p.) similarly induced hypolocomotion while failing to induce yawning. In none of these studies did rats show any signs of hyperlocomotion or any stereotyped responses normally associated with D2 or mixed D1/D2 receptor stimulation. These data suggest that hypolocomotion elicited by 7-OH-DPAT in the NAC may be mediated at the D3 receptor as distinct from the D2 dopamine receptor. We discuss the possibility that the behavioural effects we observed are mediated at D3 autoreceptors.
机译:双侧注射伏伏核(NAC)的7-羟基-N,N-二正丙基-2-氨基四氢萘(7-OH-DPAT)产生深刻的,非催化的,剂量依赖性的(总剂量为0.3-3 mg)运动不足,但不引起打哈欠。它还减少了高度优选的3%蔗糖溶液(1毫克总剂量)的摄入量。全身注射7-OH-DPAT(0.1-3.0mg / kg,腹膜内)类似地引起运动不足,而不能引起打呵欠。在这些研究中,没有一个大鼠表现出任何运动过度的迹象或任何通常与D2或D1 / D2受体混合刺激相关的刻板印象。这些数据表明,NAC中7-OH-DPAT引起的运动不足可能在D3受体处介导,与D2多巴胺受体不同。我们讨论了我们观察到的行为效应在D3受体介导的可能性。

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