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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Modulation of free intracellular calcium levels ((Ca++)i) in brain and spinal cord of morphine-tolerant rats and mice.
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Modulation of free intracellular calcium levels ((Ca++)i) in brain and spinal cord of morphine-tolerant rats and mice.

机译：吗啡耐受大鼠和小鼠脑和脊髓中游离细胞内钙水平（（Ca ++）i）的调节。

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摘要

Evaluation of the effects of tolerance to morphine in vivo on free intracellular calcium levels [(Ca++)i] in whole brain synaptosomes from rats and synaptosomes from brain regions and spinal cords of both rats and mice indicated that in whole brain and spinal cord synaptosomes, [Ca++]i levels are significantly higher in morphine-tolerant mice. Although levels do not differ between nontolerant and tolerant preparations from the rat spinal cord, [Ca++]i brain levels are significantly higher in morphine-tolerant rats. Evaluation of three brain regions from both nontolerant and tolerant rats and two brain regions from mice indicated no significant differences in basal [Ca++]i, with the exception that lower basal levels of calcium were observed in the midbrain of the tolerant rat. In vivo, mice tolerant to morphine (SC) were cross tolerant to DAMGO (IT and ICV). Cross tolerance between morphine and DAMGO was observed in vitro. No cross-tolerance was observed between morphine (SC) and the delta-agonist, DPDPE (IT or ICV), or the kappa-agonist, U50,488H (U50, IT or ICV) in vivo. Similarly, no cross tolerance was observed between morphine (SC) and DPDPE or U50 in vitro. These data indicate that tolerance in vivo induced a change in synaptosomal calcium modulation such that tolerance could be observed in vitro. Thus, a membrane component may be altered by the development of tolerance to morphine leading to an alteration in [Ca++]i in both the brain and spinal cord.
机译：评价体内对吗啡的耐受性对大鼠全脑突触小体以及大鼠和大鼠的大脑区域和脊髓突触小体中游离细胞内钙水平[（Ca ++）i]的影响表明，在全脑和脊髓突触小体中，在吗啡耐受小鼠中，[Ca ++] i水平明显更高。尽管大鼠脊髓的非耐受性和耐受性制剂之间的水平没有差异，但是吗啡耐受性大鼠的[Ca ++] i脑水平明显更高。对非耐受和耐受大鼠的三个大脑区域以及小鼠的两个大脑区域的评估表明，基础[Ca ++] i没有显着差异，但在耐受大鼠的中脑中观察到较低的基础钙水平。在体内，对吗啡（SC）耐受的小鼠对DAMGO（IT和ICV）具有交叉耐受性。体外观察到吗啡与DAMGO之间的交叉耐受性。在体内，吗啡（SC）与δ激动剂DPDPE（IT或ICV）或κ激动剂U50,488H（U50，IT或ICV）之间未观察到交叉耐受。同样，在体外吗啡（SC）与DPDPE或U50之间未观察到交叉耐受。这些数据表明体内的耐受性诱导了突触体钙调节的改变，使得可以在体外观察到耐受性。因此，膜成分可以通过对吗啡的耐受性的发展而改变，从而导致脑和脊髓中[Ca ++] i的改变。

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