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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Reinforcing properties of the neuropeptide substance P in Carassius auratus: evidence of dopaminergic system involvement.
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Reinforcing properties of the neuropeptide substance P in Carassius auratus: evidence of dopaminergic system involvement.

机译：Car鱼中神经肽物质P的增强特性：多巴胺能系统参与的证据。

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摘要

The aim of the present study was to investigate whether neuropeptide substance P (SP) has reinforcing effects in Carassius auratus and whether this effect could be related to dopaminergic neurotransmission. For this purpose fishes were put in a three-compartment box in which one compartment gave access to two others that did not directly link. The time spent in each compartment was registered for 10 min to determine a possible preferred compartment. Twenty-four hours later, the fish were given one of the following intraperitoneal treatments: a) Group VEH, injected with the vehicle of substance P; b) Group SP25, injected with SP, 25 micrograms/kg body wt.; c) Group SP50, injected with SP, 50 micrograms/kg; or d) Group HALO, injected with haloperidol (2 mg/kg) 30 min before an injection of SP (50 micrograms/kg). Immediately after the treatment the fish were kept for 30 min in the compartment preferred least the day before. On the next day the fish were retested for 10 min to verify the time spent in eachcompartment. The results indicate that SP at the dose of 50 micrograms/kg enhanced the time spent on the paired compartment, and that the pretreatment with haloperidol abolished this enhancement. It is suggested that SP has reinforcing effects in C. auratus that may be mediated by the dopaminergic system.
机译：本研究的目的是调查神经肽物质P（SP）在ura鱼中是否具有增强作用，以及该作用是否与多巴胺能神经传递有关。为此，将鱼放在一个三格的盒子中，其中一个格可以通向另外两个不直接相连的格。记录每个隔室中花费的时间10分钟，以确定可能的首选隔室。二十四小时后，对鱼进行了以下腹膜内处理之一：a）VEH组，注射了P物质载体; b）SP25组，注射SP，剂量为25微克/千克体重; c）SP50组，注射SP，50微克/千克;或d）HALO组，在注射SP（50微克/ kg）前30分钟注射氟哌啶醇（2 mg / kg）。处理后立即将鱼在隔室中放置至少30分钟，最好至少在前一天。第二天，对鱼进行了10分钟的重新测试，以验证在每个隔间中所花费的时间。结果表明，以50微克/ kg的剂量使用SP可以延长配对室的时间，而氟哌啶醇的预处理则可以消除这种增强。提示SP在金黄色葡萄球菌中具有增强作用，这可能是由多巴胺能系统介导的。

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