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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Glycine enhances the central depressant properties of ethanol in mice.
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Glycine enhances the central depressant properties of ethanol in mice.

机译：甘氨酸增强小鼠乙醇的中枢抑制特性。

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摘要

The interaction between ethanol and glycine in the central nervous system was investigated in male Swiss-Webster mice. The loss of the righting reflex (LORR) was used as a measure of central nervous system depression. Mice were injected with ethanol (4.0 g/kg, IP), causing an ethanol-induced LORR. Immediately after the animals regained the righting reflex from ethanol administration, they received an intracerebroventricular (ICV) injection of saline or glycine (1, 15, 25, or 50 mumol/kg) in a volume of 5 microliters. Upon ICV injection of glycine, the mice lost the righting reflex once again. This effect of glycine in the presence of ethanol occurred rapidly and in a dose-dependent manner. Glycine induced a return to the LORR of 12.6 +/- 0.7, 24.5 +/- 1.3, 32.8 +/- 2.0, and 46.8 +/- 4.5 min when doses of 1, 15, 25, and 50 mumol/kg, respectively, were injected. D-Serine (15, 25, or 50 mumol/kg), an amino acid precursor of glycine, was injected (ICV) after the animals regained the righting reflex following ethanol injection (IP). Serine caused a return to the LORR of 0.5 +/- 0.5, 6.0 +/- 1.0, and 6.5 +/- 0.9 min when doses of 15, 25, and 50 mumol/kg, respectively, were injected. Strychnine was used to attenuate the ability of glycine and serine to cause a return to the LORR in the presence of ethanol. Strychnine, a competitive antagonist of glycine, significantly reduced the ability of glycine and serine to enhance the depressant action of ethanol.(ABSTRACT TRUNCATED AT 250 WORDS)
机译：在雄性Swiss-Webster小鼠中研究了乙醇和甘氨酸在中枢神经系统之间的相互作用。扶正反射丧失（LORR）被用作中枢神经系统抑制的量度。给小鼠注射乙醇（4.0 g / kg，IP），引起乙醇诱导的LORR。在动物从乙醇中恢复了对正反射后，立即接受了5微升体积的脑室内（ICV）注射的盐水或甘氨酸（1、15、25或50μmol/ kg）。 ICV注射甘氨酸后，小鼠再次失去扶正反射。甘氨酸在乙醇存在下的这种作用以剂量依赖的方式迅速发生。当剂量分别为1、15、25和50μmol/ kg时，甘氨酸诱导的LORR分别为12.6 +/- 0.7、24.5 +/- 1.3、32.8 +/- 2.0和46.8 +/- 4.5分钟，被注射。在动物注射乙醇（IP）后恢复扶正反射后，注射甘氨酸的氨基酸前体D-Serine（15、25或50 mumol / kg）。当分别注射15、25和50 mumol / kg的剂量时，丝氨酸导致LORR返回0.5 +/- 0.5、6.0 +/- 1.0和6.5 +/- 0.9分钟。在乙醇存在下，士的宁被用于减弱甘氨酸和丝氨酸引起LORR返回的能力。 Strychnine是甘氨酸的竞争性拮抗剂，可显着降低甘氨酸和丝氨酸增强乙醇抑制作用的能力。（摘要截断为250字）

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