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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Responses of Swiss-Webster mice to repeated plus-maze experience: further evidence for a qualitative shift in emotional state?
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Responses of Swiss-Webster mice to repeated plus-maze experience: further evidence for a qualitative shift in emotional state?

机译：Swiss-Webster小鼠对反复迷宫经历的反应：情绪状态发生质变的进一步证据？

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Behavioral, endocrinological, and pharmacological data suggest that the emotional response of rodents to the elevated plus-maze alters as a function of prior test experience. In the present study, 74 intact male Swiss-Webster mice were exposed to the plus-maze for 5 min on each of 3 consecutive days, with all test sessions recorded on videotape. Behavior patterns for each trial were scored using ethological analysis software and the resultant database subjected to a number of statistical treatments. Analysis of full session profiles (i.e., 5 min total scores) showed that a single prior undrugged experience of the maze increases behavioral indices of anxiety and that these alterations are either maintained or further enhanced on subsequent trials. Furthermore, the behavioral profile evident by trial 3 was largely unchanged when animals were reexposed to the maze 10 days later. More detailed (i.e., min by min) examination of behavior patterns within and between trials demonstrated that unambiguous open arm avoidance is acquired by the third minute of trial 1, and that the behavioral profile evident by the end of trial 1 is (a) markedly different to that seen at the beginning of that trial, and (b) generally maintained or even accentuated on trials 2 and 3. The implied impact of prior test experience on future behavioral strategy in the maze was strongly supported by a series of factor analyses. Thus, while the factor associations of vertical activity and directed exploration remained constant across trials, trial 2 and 3 anxiety measures loaded on a separate factor to that loading trial 1 anxiety measures. A similar trial 1 vs. trials 2 and 3 dissociation was observed for measures of locomotor activity. Although the present findings are consistent with the proposal that prior test experience produces a qualitative shift in emotional response to the elevated plus-maze, the precise basis for this change as well as its full significance for our understanding of anxiety-related processes remain to be determined.
机译：行为，内分泌和药理学数据表明，啮齿动物对升高的迷宫的情绪反应根据先前的测试经验而改变。在本研究中，将74只完整的雄性Swiss-Webster小鼠连续3天每天暴露于迷宫中5分钟，所有测试均记录在录像带上。使用种族学分析软件对每个试验的行为模式进行评分，并对所得数据库进行多种统计处理。对完整会话概况（即5分总分）的分析表明，以前在迷宫中不加药的单个经历会增加焦虑行为指数，并且这些改变在随后的试验中得以维持或进一步增强。此外，当动物在10天后再次暴露于迷宫中时，试验3所显示的行为特征在很大程度上没有改变。对试验内和试验间行为模式的更详细（即逐分钟）检查表明，在试验1的第三分钟即可明确避免张开双臂，并且在试验1结束时明显的行为特征是（a）与该试验开始时看到的结果不同，并且（b）通常对试验2和3保持不变甚至更加强调。先前的测试经验对迷宫中未来行为策略的隐含影响得到了一系列因素分析的有力支持。因此，尽管垂直活动和定向勘探的因素关联在各个试验中保持不变，但试验2和3的焦虑测量值与试验1的焦虑测量值是不同的。观察到类似的试验1与试验2和3的解离可以测量运动能力。尽管目前的发现与先前的测试经验对高迷宫情绪反应产生质变的建议相一致，但这种变化的确切基础及其对我们理解与焦虑相关过程的全面意义仍有待进一步研究。决心。

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