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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >The influence of postweaning housing conditions on drug-induced conditioned taste aversion.
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The influence of postweaning housing conditions on drug-induced conditioned taste aversion.

机译：断奶后的住房条件对药物引起的条件性厌恶感的影响。

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摘要

Postweaning social isolation can influence the sensitivity of rats to several effects of drugs of abuse. The present study investigated the influence of postweaning housing conditions on the sensitivity of rats to the aversive effects of a number of psychoactive agents using a conditioned taste aversion (CTA) test procedure. Development of a CTA was assessed by pairing administration of the drug with the consumption of a 0.05% (weight/volume) saccharin solution in water-deprived (18 h) rats in a 20 min drinking period. Saccharin consumption was then measured in 20 min test sessions over the next 4 consecutive days. Consumption of saccharin solution was significantly reduced in both isolated and enriched rats following administration of d-amphetamine (2 mg/kg), cocaine (30 mg/kg), morphine (10 mg/kg), nicotine (1.0 mg/kg), caffeine (20 mg/kg), alcohol (1.5 g/kg), and LiCl (0.15 M, 4 ml/kg). There was no significant effect of housing conditions on the CTA induced by cocaine, nicotine, alcohol, or LiCl; however, isolation-reared rats were found to be less sensitive to the aversive effects of d-amphetamine, morphine, and caffeine in this paradigm. These results suggest that rearing rats in social isolation induces an attenuation in sensitivity to the aversive effects of some psychoactive agents.
机译：断奶后的社会隔离可以影响大鼠对多种滥用药物的敏感性。本研究使用条件性味觉厌恶（CTA）测试程序研究了断奶后的住房条件对大鼠对多种精神活性剂的厌恶作用的敏感性的影响。通过在20分钟的饮水时间内，在缺水（18 h）大鼠中，将药物与0.05％（重量/体积）糖精溶液的消耗量配对使用，评估CTA的发生。然后在接下来的连续4天的20分钟测试中测量糖精消耗量。给予d-苯异丙胺（2 mg / kg），可卡因（30 mg / kg），吗啡（10 mg / kg），尼古丁（1.0 mg / kg），咖啡因（20 mg / kg），酒精（1.5 g / kg）和LiCl（0.15 M，4 ml / kg）。可卡因，尼古丁，酒精或LiCl诱导的CTA对居住条件没有明显影响。然而，在这种范例中，发现隔离饲养的大鼠对d-苯异丙胺，吗啡和咖啡因的厌恶作用不那么敏感。这些结果表明，在社会隔离中饲养大鼠会导致对某些精神活性剂的厌恶作用的敏感性降低。

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