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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effects of propranolol, buspirone, pCPA, reserpine, and chlordiazepoxide on open-field behavior.
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Effects of propranolol, buspirone, pCPA, reserpine, and chlordiazepoxide on open-field behavior.

机译：普萘洛尔，丁螺环酮，pCPA，利血平和氯二氮卓对旷场行为的影响。

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The study examined the possibility that propranolol, buspirone, pCPA, and reserpine have antianxiety effects by comparing their effects with those of chlordiazepoxide on an open-field test of emotionality in rats. The effects of intraperitoneal injections of d,l, propranolol (5, 10, 20 mg/kg), buspirone (1.25, 2.5, 5 mg/kg), reserpine (0.5 mg/kg), parachlorophenylalanine (pCPA) (100 mg/kg), and chlordiazepoxide (CDP) (2.5, 5, 10 mg/kg) were compared with performance of rats under saline or water using an open-field test on 5 successive days. Significant effects were found on peripheral movements, rearing, grooming, immobility, and defecation. The patterns of effects of high doses of propranolol and buspirone resembled those of CDP, while pCPA had some of the effects of CDP, and reserpine produced few effects. With propranolol, buspirone, and CDP, there was evidence of dose sensitivity. The effects of repeated testing across 5 days were different from these of CDP or other drugs. The results are consistent with the hypothesis that the effects of propranolol and buspirone on open-field behavior are anxiolytic, and may be mediated by action on the same brain systems.
机译：该研究通过在大鼠的开放式情绪测试中比较了普萘洛尔，丁螺环酮，pCPA和利血平与氯地西oxide的抗焦虑作用，从而研究了它们的抗焦虑作用。腹腔注射d，l，普萘洛尔（5、10、20 mg / kg），丁螺环酮（1.25、2.5、5 mg / kg），利血平（0.5 mg / kg），对氯苯丙氨酸（pCPA）（100 mg /连续5天使用开放视野测试，将氯二氮卓（CDP）（2.5、5、10 mg / kg）与在盐水或水中的大鼠的性能进行比较。发现对周围运动，抚养，修饰，固定和排便有显着影响。高剂量的普萘洛尔和丁螺环酮的作用方式与CDP相似，而pCPA对CDP有一定作用，而利血平几乎没有作用。对于普萘洛尔，丁螺环酮和CDP，有剂量敏感性的证据。 5天重复测试的效果与CDP或其他药物的效果不同。该结果与以下假设相一致：普萘洛尔和丁螺环酮对旷场行为的影响具有抗焦虑作用，并且可能由对同一大脑系统的作用介导。

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