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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Prenatal morphine exposure induces age-related changes in seizure susceptibility in male rats.
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Prenatal morphine exposure induces age-related changes in seizure susceptibility in male rats.

机译：产前吗啡暴露可引起雄性大鼠癫痫发作的年龄相关变化。

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摘要

The purpose of this study was to investigate the effects of prenatal exposure to morphine (5-10 mg/kg on days 11-18 of gestation) on flurothyl seizure susceptibility in adult and developing male rats. In adult rats, prenatal morphine exposure increased the threshold to clonic seizures but not to tonic-clonic seizures. The effects of prenatal morphine exposure on clonic seizures were age dependent. At postnatal day (PND) 15, prenatal drug exposure did not alter the seizure threshold. At PND 25, there was a reduction in the threshold but by PND 38, the clonic seizure threshold was increased and this increase persisted into adulthood. Prenatal exposure to morphine did not alter the tonic-clonic seizure threshold in any age group of intact male rats. A group of male rats prenatally exposed to morphine was gonadectomized in adulthood. In gonadectomized rats both clonic and tonic-clonic thresholds were increased. These results suggest that exposure to morphine during mid to late gestation induces age-dependent alterations in the susceptibility to clonic but not tonic-clonic seizures. In adult male rats the threshold to tonic-clonic seizures is influenced by prior gonadectomy in adulthood.
机译：这项研究的目的是调查成年和成年雄性大鼠产前暴露于吗啡（妊娠第11-18天为5-10 mg / kg）对氟尿嘧啶癫痫发作敏感性的影响。在成年大鼠中，产前吗啡暴露增加了阵挛性癫痫发作的阈值，但没有增加强直阵挛性癫痫发作的阈值。产前吗啡暴露对阵挛性癫痫发作的影响与年龄有关。在产后第15天（PND），产前药物暴露并未改变癫痫发作阈值。在PND 25时，阈值降低，但到PND 38时，阵挛性癫痫发作阈值增加，这种增加持续到成年。产前暴露于吗啡不会改变任何年龄段完整雄性大鼠的强直阵挛性癫痫发作阈值。一组成年前接受吗啡的产前暴露于吗啡的雄性大鼠。在淋巴切除的大鼠中，慢性和强直-慢性阈值均升高。这些结果表明，在妊娠中期至晚期暴露于吗啡会引起年龄依赖性的阵挛性发作而不是强直性阵挛性癫痫发作的改变。在成年雄性大鼠中，成年先兆性腺切除术会影响强直阵挛性癫痫发作的阈值。

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