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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Nicotine administration impairs sensory gating in Long-Evans rats.
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Nicotine administration impairs sensory gating in Long-Evans rats.

机译：尼古丁给药会损害Long-Evans大鼠的感觉门控。

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In rats, effects of nicotine administration on sensory gating as indexed by prepulse inhibition (PPI) of the acoustic startle reflex (ASR) are unclear. We have found that nicotine administration enhances ASR and PPI in Sprague-Dawley rats, but other investigators, using Long-Evans rats, have reported no effects or enhancement of PPI only. Numerous methodological differences exist among studies in addition to subject strain, however, making it unclear whether inconsistent behavioral responses are the result of different experimental procedures or indicate a true strain difference. To investigate the role of strain in nicotine's effects on ASR and PPI, 192 male and female Long-Evans rats were administered 12 mg/kg/day nicotine via osmotic minipump for 14 days using identical methodologies employed in studies with Sprague-Dawley subjects. Effects of grouped vs. individual housing on these responses also were examined. Nicotine administration impaired ASR and PPI in Long-Evans subjects. These effects occurred in female rats regardless of housing condition, and interacted with housing in male rats. Results indicate that sex and housing are important variables in nicotine's effects. Results suggest that subject strain may be an important variable in nicotine's effects on sensory gating, and that responses of Sprague-Dawley vs. Long-Evans rats may represent a true strain difference.
机译：在大鼠中，尼古丁给药对感觉门控的影响尚不清楚，而声门惊吓反射（ASR）的脉冲前抑制（PPI）则表明了这种作用。我们已经发现，尼古丁给药可增强Sprague-Dawley大鼠的ASR和PPI，但其他研究者使用Long-Evans大鼠仅报道没有作用或增强PPI。在研究之间，除了受试者的品系外，还存在许多方法上的差异，因此，尚不清楚行为反应是否是不同实验程序的结果还是真正的品系差异。为了研究菌株在尼古丁对ASR和PPI的影响中的作用，采用与Sprague-Dawley受试者研究相同的方法，通过渗透微型泵向192只雄性和雌性Long-Evans大鼠服用12 mg / kg /天的尼古丁，持续14天。还研究了分组住房与个人住房对这些反应的影响。尼古丁给药会损害Long-Evans受试者的ASR和PPI。这些作用发生在雌性大鼠中，而与居住条件无关，并且与雄性大鼠中的住房相互作用。结果表明，性别和住房是尼古丁影响的重要变量。结果表明，受试者的应变可能是尼古丁对感觉门控影响的重要变量，Sprague-Dawley与Long-Evans大鼠的反应可能代表了真实的应变差异。

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