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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Cocaine produces panic-like flight responses in mice in the mouse defense test battery.
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Cocaine produces panic-like flight responses in mice in the mouse defense test battery.

机译：可卡因在小鼠防御试验电池中在小鼠中产生恐慌状的飞行反应。

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摘要

There is an emerging body of clinical evidence that cocaine use in humans can result in serious fear or panic-related emotional disturbances. The present study evaluated the effects of cocaine administration upon defensive responses of mice to a predator (rat) in a Mouse Defense Test Battery (MDTB) that permits the display of the full range of the mouse defensive behaviors: avoidance/escape, flight, freezing, defensive upright, and defensive threat and attack. Mice were tested 30 min following intraperitoneal (IP) injections of either 0, 10, 20, or 30 mg/kg cocaine hydrochloride suspended in physiological saline. Cocaine produced an increase in flight and escape responses throughout the subtests comprising the MDTB. The percentage of subjects exhibiting escape increased in cocaine-treated mice in the Predator Avoidance Test. Cocaine increased mean flight speed and maximum flight speed in the Flight/Chase Test; frequency of flight responses in the Straight Alley Test; and the number of flight attempts in the Forced Contact test. The predominance of flight responding throughout the tests masked any possible cocaine effects on other defenses. The present findings indicate that cocaine may exert its panic-producing effects by acting upon particular neurobehavioral systems subserving defensive behavior.
机译：有大量的临床证据表明，在人类中使用可卡因会导致严重的恐惧或与恐慌相关的情绪障碍。本研究在小鼠防御测试电池（MDTB）中评估了可卡因给药对小鼠对捕食者（大鼠）防御反应的影响，该电池可显示小鼠的所有防御行为：避免/逃避，逃跑，冻结，防御直立以及防御性威胁和攻击。腹膜内（IP）注射悬浮于生理盐水中的0、10、20或30 mg / kg盐酸可卡因后，对小鼠进行30分钟测试。在包括MDTB的所有子测试中，可卡因使飞行和逃逸反应增加。在“捕食者回避测试”中，可卡因治疗的小鼠中表现出逃避的受试者百分比增加。可卡因提高了飞行/追逐测试中的平均飞行速度和最大飞行速度;直巷测试中的飞行响应频率;以及“强制接触”测试中的飞行尝试次数。在整个测试过程中，飞行反应的优势掩盖了可卡因对其他防御系统的任何影响。目前的发现表明，可卡因可能通过对保护防御行为的特定神经行为系统起作用而发挥其惊恐作用。

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