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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Dextromethorphan alters methamphetamine self-administration in the rat.
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Dextromethorphan alters methamphetamine self-administration in the rat.

机译：右美沙芬改变了大鼠体内的甲基苯丙胺自我管理。

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Various lines of evidence indicate that methamphetamine (METH) self-administration in rats is under dopaminergic control, and NMDA receptors have been shown to control the release of dopamine at its synapse. Consequently, the aim of this study was to observe the effects of dextromethorphan (DM), a non-competitive NMDA antagonist, in rats self-administering METH. The hypothesis was that acute pretreatment of DM (25 mg/kg) would alter response to METH. DM significantly altered self-administration by reducing the number of correct responses for three METH self-administration doses (0.05, 0.1, 0.25 mg/kg). The same pretreatment did not affect responding for food reward. These findings show that the DM was able to selectively alter METH self-administration.
机译：各种证据表明，大鼠的甲基苯丙胺（METH）自我给药处于多巴胺能控制之下，并且已显示NMDA受体可控制多巴胺在突触中的释放。因此，本研究的目的是观察非竞争性NMDA拮抗剂右美沙芬（DM）在自我给药METH的大鼠中的作用。假设是DM的急性预处理（25 mg / kg）会改变对METH的反应。 DM通过减少三种METH自我给药剂量（0.05、0.1、0.25 mg / kg）的正确应答次数，显着改变了自我给药。相同的预处理不影响对食物奖励的响应。这些发现表明，DM能够选择性地改变METH的自我管理。

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